02340nam 2200361 450 991067437360332120230629135247.0(CKB)4920000000094777(NjHacI)994920000000094777(EXLCZ)99492000000009477720230629d2018 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierAdvances in micro-bioreactor design for organ cell studies /edited Carl-Fredrik MandeniusBasel, Switzerland :MDPI - Multidisciplinary Digital Publishing Institute,[2018]©20181 online resource (vii, 157 pages) illustrations3-03897-233-9 Includes bibliographical references.Micro-bioreactors offer unique opportunities to study biological systems under fluidic conditions. The concept of micro-bioreactors suggests that biological reaction conditions at a large scale can be scaled down to micro-volumes while maintaining performance and functionality. Models and operation principles can be simulated at a smaller scale, either by scaling down organs in the human body, or bioreactors for the production of biologics. This book highlights these issues with much focus on new engineering design approached. Initial chapters cover conceptual design of microbioreactors and organ-on-chips, and the role of microbioreactors in tissue engineering for the clinical and for therapeutic targets. Two chapters are dedicated to microbioreactors for implementing tumour models. Other chapters discuss three-dimensional models for hepatic and cardiac cells for toxicity testing and drug evaluation. Finally, the design of organ chips for cartilage scaffolds and integration of sensors are covered in separate chapters. We believe the book have substantial value for researchers active in bioreactor engineering, drug development and cell physiology as well as readers interested in the these topics.BioreactorsBioreactors.660.6Mandenius Carl-FredrikNjHacINjHaclBOOK9910674373603321Advances in Micro-Bioreactor Design for Organ Cell Studies2932998UNINA