03986oam 2200613 450 991013708830332120230621140048.09782889196449(CKB)3710000000824754(oapen)https://directory.doabooks.org/handle/20.500.12854/40472(EXLCZ)99371000000082475420191103h20152015 fy| 0engurcn#---||||ntxtrdacontentcrdamediacrrdacarrierAging, neurogenesis and neuroinflammation in hearing loss and protection /Marta Magariños, Marta Milo and Isabel Varela-NietoFrontiers Media SA2015[Lausanne, Switzerland] :Frontiers Media SA,[2015]©20151 online resource (151 pages) illustrations (chiefly colour); digital file(s)Frontiers Research TopicsPrint version: 2889196445 Includes bibliographical references.Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly. Still the molecular bases of ageing in the vestibular system have not been studied in detail. Genetic and environmental factors contribute to the progression of age-related hearing loss (ARHL). Being noise the main environmental noxious agent for human hearing in the industrialized societies.There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease.In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes involved in ageing as senescence and autophagy, to molecules essential for hearing as IGF-1 and neurotrophins. Neuroinflammation takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Neurogenesis is also essential to understand the adult cochlea self-repair potential. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies.Frontiers research topics.PresbycusisVestibular apparatusDeafnessEtiologyDeafnessTreatmentTGF-betaNoiseHair cellsredox balancespiral ganglion neuronsDrug deliveryARHLAuditory CortexLipid homeostasisInner earPresbycusis.Vestibular apparatus.DeafnessEtiology.DeafnessTreatment.617.8Marta Magarinosauth1366880Magariños MartaMilo MartaVarela-Nieto IsabelUkMaJRU9910137088303321Aging, neurogenesis and neuroinflammation in hearing loss and protection3389399UNINA03428nam 2200877z- 450 991067403280332120210501(CKB)5400000000042702(oapen)https://directory.doabooks.org/handle/20.500.12854/68961(oapen)doab68961(EXLCZ)99540000000004270220202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Contribution of Food Oral ProcessingBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (110 p.)3-03936-834-6 3-03936-835-4 When food is ingested, it remains in the mouth for a short period of time. Although this period is brief compared to the total food nutrient digestion and absorption time, it is crucially important, as it is the first step in digestion. It is also very important that, while the food is in the mouth, it is perceived by the senses and then a decision is made on swallowing. Oral sensory perception is an integrative response, which is generated in very short time (normally a few seconds) from complex information gathered from multiple sources during mastication and swallowing. Consequently, food oral processing studies include many orientations. This Special Issue brings together a small range of studies with a diversity of approaches that provide good examples of the complexity and multidisciplinarity of the subject.Biology, life sciencesbicsscFood & societybicsscResearch & information: generalbicsscaroma compoundartificial tonguebodycare foodcarrotschewing simulatorcomplementary porridgecompression testdensitydynamic perceptionflavor releasefracturegellan gum gelsin vitroin vitro oral fragmentationin-mouth sensory perceptioninfantInternational Dysphagia Diet Standardization Initiative (IDDSI)lipoprotein matrixmalnutritionmasticationoral parametersoral phase of starch hydrolysisoral processingparticle sizepureed foodssensorimotor readinesssoft machinestarchswallowingTCATAtemporal check-all-that-apply (TCATA)temporal dominance of sensations (TDS)temporal dynamic measurementstexturetrained and expert panelviscositywine texturexanthanBiology, life sciencesFood & societyResearch & information: generalFiszman Susanaedt1338944Tarrega AmparoedtFiszman SusanaothTarrega AmparoothBOOK9910674032803321The Contribution of Food Oral Processing3059238UNINA02080nam 2200481z- 450 991055744410332120211118(CKB)5400000000043281(oapen)https://directory.doabooks.org/handle/20.500.12854/72927(oapen)doab72927(EXLCZ)99540000000004328120202111d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierSeed Dormancy, Germination and Pre-Harvest SproutingFrontiers Media SA20191 online resource (235 p.)Frontiers Research Topics2-88945-762-1 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contactBotany and plant sciencesbicsscScience: general issuesbicsscCereal CropsDormancyGenesGenetic engineeringOmicsPre-harvest sproutingBotany and plant sciencesScience: general issuesLi Chengdaoedt1312866Nonogaki HiroedtBarrero  JoseedtLi ChengdaoothNonogaki HiroothBarrero  JoseothBOOK9910557444103321Seed Dormancy, Germination and Pre-Harvest Sprouting3031045UNINA