03472nam 2200805z- 450 991067401300332120231214133533.0(CKB)5680000000037611(oapen)https://directory.doabooks.org/handle/20.500.12854/81046(EXLCZ)99568000000003761120202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative BacteriaBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (190 p.)3-0365-3946-8 3-0365-3945-X Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens.Research & information: generalbicsscBiology, life sciencesbicsscMicrobiology (non-medical)bicsscMdtF (YhiV)multidrug resistanceRND-type efflux pumpdye accumulationreal-time effluxpathogensRNDevolutionefflux pumpadaptationAliarcobacter butzleriRND efflux pumpsvirulenceresistanceRND pumpdominant negative effectassemblyprotein-protein interactionmutationdrug resistancecystic fibrosisprevalence of efflux resistance mechanismshospital acquired infectionsantibiotic resistanceallosteryantimicrobial resistanceconformational changesenergetic transitiongram-negative bacteriapump activationResearch & information: generalBiology, life sciencesMicrobiology (non-medical)Broutin Isabelleedt1339339Vargiu Attilio VedtVenter HenriettaedtPhan GillesedtBroutin IsabelleothVargiu Attilio VothVenter HenriettaothPhan GillesothBOOK9910674013003321The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria3060056UNINA