05057nam 22015133a 450 991067400960332120250203235430.09783039210831303921083110.3390/books978-3-03921-083-1(CKB)4920000000094815(oapen)https://directory.doabooks.org/handle/20.500.12854/61371(ScCtBLL)8bd267cb-866f-46c6-87e7-02a7821517e4(OCoLC)1126206907(oapen)doab61371(EXLCZ)99492000000009481520250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierTRP Channels in Health and DiseaseAlexander DietrichMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (266 p.)9783039210824 3039210823 Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for "canonical", TRPA with A for "ankyrin", TRPM with M for "melastatin", TRPML with ML for "mucolipidin", TRPP with P for "polycystin", and TRPV with V for "vanilloid". Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in "Cells" summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options. Medicinebicssctransient receptor potential channelsphotochromic ligandselementary immunologyPurkinje cellEPSCsubstance Pchemicalsorgan toxicitylymphocytesHSP70physiologybioavailableinflammatory bowel diseaseplateletspollutantsyeastregulatory T cellskinaseSaccharomyces cerevisiaemanganesecerebellumTRP channelNHERFinflammationnanoHPLC-ESI MS/MSTRPM7chemical probesTRPM8dorsal column nucleiTRPV2TRPV3calcitonin gene-related peptideTRPV1ion channelstransient receptor potential2D gel electrophoresisMALDI-TOF MS(/MS)TRPV4overproductionsulfur mustardoxidative stressgraft versus host diseasementholtopicalchemosensorAP18calcium signallingmucosal epitheliumcuneate nucleusproduction platformTRPC channelsulcerative colitischannel structurexerostomianeutrophilscardiovascular systemTRPC5TRPC6TRPC3TRPC4calcium signalingprotein purificationadipose tissuetransient receptor potential (TRP) channelssodiumTH17diacylglycerolhypersensitivityTRPY1GABABHEK293thrombosision channelTRPCpathophysiologySMADtoxicologyendotheliumcalciumproteomicsTRPA1salivary glandsTRP channelslipid mediatorssensorsradiationTRPM4 channelhuman medulla oblongatamGluR1small moleculesTRPC3 pharmacologyMedicineDietrich Alexander764160ScCtBLLScCtBLLBOOK9910674009603321TRP Channels in Health and Disease3059186UNINA