02406nam 2200361 450 991067400760332120230622221803.0(CKB)4100000002152768(NjHacI)994100000002152768(EXLCZ)99410000000215276820230622d2018 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierFrom Ptolemaus to Copernicus The Evolving System of Gluten-Related Disorder /Carlo Catassi, Alessio FasanoBasel :MDPI - Multidisciplinary Digital Publishing Institute,2018.1 online resource (238 pages)3-03842-731-4 Annotation Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the "center of the universe," but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a "work in progress." Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.From Ptolemaus to CopernicusGlutenGluten.613.282Catassi Carlo504904Fasano AlessioNjHacINjHaclBOOK9910674007603321From Ptolemaus to Copernicus3392280UNINA