01007nam2-2200349---450 99000089248020331620200907101113.00089248USA010089248(ALEPH)000089248USA01008924820020122d1962----km-y0itay0103----baitaIT||||||||001yySeries collectionum1Romaeapud Istituto storico italiano per il Medio Evo1962XVIII, 819 p26 cm200100100502292001Repertorium fontium historiae Medii AeviStoria medievaleFonti909.07ITsalbcISBD990000892480203316X.1.A. 15/1 (XI A CONT. 1/1)38325 L.M.X.1.A.X.1.A. 15/1a (XI A CONT. 1/1 BIS)57132 L.M.X.1.A.FC M 2008/14086 DLMFC MBKUMADILAMSeries collectionum970096UNISA03097nam 2200385 450 991064720490332120230328011226.0(CKB)5680000000300255(NjHacI)995680000000300255(EXLCZ)99568000000030025520230328d2023 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierCRISPR Technology Recent Advances /edited by Yuan-Chuan ChenLondon :IntechOpen,2023.©20231 online resource (ix, 158 pages)1-80356-815-1 1-80356-816-X Preface -- Section 1 Introduction -- Chapter 1 Introductory Chapter: CRISPR Technology by Yuan-Chuan Chen -- Chapter 2 Emerging CRISPR Technologies by Annelise Cassidy and Stephane Pelletier -- Section 2 Technology -- Chapter 3 Maximizing the Efficacy of CRISPR/Cas Homology-Directed Repair Gene Targeting by Terry S. Elton, Md. Ismail Hossain, Jessika Carvajal-Moreno, Xinyi Wang, Dalton J. Skaggs and Jack C. Yalowich -- Chapter 4 The Prominent Characteristics of the Effective sgRNA for a Precise CRISPR Genome Editing by Reza Mohammadhassan, Sara Tutunchi, Negar Nasehi, Fatemeh Goudarziasl and Lena Mahya -- Chapter 5 Recent Advances in In Vivo Genome Editing Targeting Mammalian Preimplantation Embryos by Masahiro Sato, Masato Ohtsuka, Emi Inada, Shingo Nakamura, Issei Saitoh and Shuji Takabayashi -- Section 3 Application -- Chapter 6 Applications of CRISPR/Cas9 for Selective Sequencing and Clinical Diagnostics by Maximilian Evers, Björn Brändl, Franz-Josef Müller, Sönke Friedrichsen and Stephan Kolkenbrock.CRISPR technology has been extensively used in vitro and in vivo as a tool in basic research for genetic editing (e.g., genome encoding, silencing, enhancing, and modification). Although there are many technical and ethical challenges to overcome, such as off-target effects, delivery tool selection, and safety concerns, scientists are working to improve this technology. CRISPR technology is promising for practical applications as well as for laboratory work and basic research. Currently, CRISPR is being used successfully in microbial detection, disease diagnosis, and manufacturing of agricultural products, food, industrial products, and medicinal products. The development of medicinal products using CRISPR will open a new era for human therapeutics and may bring hope for the recovery of ill patients. This book provides a comprehensive overview of CRISPR technology. It examines its discovery, improvement, and implications, explores its technology and applications, and discusses perspectives and challenges.CRISPR Technology CRISPR (Genetics)CRISPR (Genetics)576.5Chen Yuan-ChuanNjHacINjHaclBOOK9910647204903321CRISPR Technology3085925UNINA02520oas 2201129 a 450 991014505190332120251114213013.01873-5835(DE-599)ZDB2008028-1(DE-599)2008028-1(OCoLC)39061097(CONSER) 2007233003(CKB)954925473398(EXLCZ)9995492547339819980505a19779999 sy aengurmnu||||||||txtrdacontentcrdamediacrrdacarrierLeukemia researchOxford ;New York Pergamon©1977-Refereed/Peer-reviewedTitle from contents screen (ScienceDirect, viewed Mar. 2, 2007).Published: Elsevier, <2007->0145-2126 LeukemiaPeriodicalsLeukemiaLeukemiaPeriodicalsLeukemiaLeucémiePériodiquesLeucémieLeukemiafast(OCoLC)fst00996894Leukemiegttperiodicals.aatPeriodicals.fastPeriodicals.lcgftPériodiques.rvmgfLeukemiaLeukemia.LeukemiaLeukemia.LeucémieLeucémie.Leukemia.Leukemie.616OH1OH1OCLOCLCQGUAU9SGUAOCLCQOCLCOOCLCQOPELSBUFOPELSOCLCFCOOVT2EUWOCLCQNLEU3WEZCOCLCOFQMOCLCOAU@OCLCOWYUOCLCOUKMGBAUDTKNOCLCOOCLCQUABOCLCLCUDKQWZ5ALIPLNDNJTWURSTCNTRULVTDKUOCLCQJOURNAL9910145051903321Leukemia research1413632UNINA