05297nam 2201429z- 450 991063999670332120231214132843.03-0365-6099-8(CKB)5470000001633386(oapen)https://directory.doabooks.org/handle/20.500.12854/95875(EXLCZ)99547000000163338620202301d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMicro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical ApplicationsBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (232 p.)3-0365-6100-5 Recently, microfluidic, nanofluidic and lab-on-a-chip devices have gained particular attention in biomedical applications. Due to their advantages, such as miniaturization, versatility, ease of use, cost-effectiveness, and the potential to replace animal models for drug development and testing, these devices hold tremendous potential to revolutionize the research of more effective treatments for several diseases that threaten human life. With integrated biosensors, these devices allow the development and design of micro- and nanoparticles to be studied in detail, modelling human physiology, investigating the molecular and cellular mechanisms underlying disease formation and progression, and gaining insights into the performance and long-term effects of responsive drug delivery nanocarriers. This Special Issue gathered research papers, and review articles focusing on novel microfluidic, nanofluidic and lab-on-a-chip devices for biomedical applications, addressing all steps related to fabrication, biosensor integration and development, characterization, numerical simulations and validation of the devices, optimization and, the translation of these devices from research labs to industry settings.Medicinebicsscprotein biomarkermicroarraymicrofluidic cassettemultiplex measurementimmunoassaypoint-of-care testingmicrofluidic devicesmall intestineex vivohistologyembedded resinsectioningpeptide biosensorlab-on-a-chiplabel-free detectionpeptide aptamersprotein biomarkersmicrofluidic biochiptroponin Tcomputational simulationsdrug discoveryorgan-on-a-chipmicrofluidic devicespreclinical modelsnumerical simulationsautomationnon-enzymaticDNA amplificationL-DNAmicrofluidicfluorescencepaper microfluidicssweatsensinghydrogelslactateosmotic pumpingevaporationcapillarywickingbiochemical assaymicrofluidicscell trapRBCevolutionary algorithmgenerative designartificial intelligenceorgan-on-chipliver-on-chipliver diseasemulti-level microfluidic devicelive cell imaginglong-term microscopy imagingfocus driftingimmersion oil viscositybacterial population dynamicssingle-cell studiesE. colimother machinecomputational fluid dynamicscancer-on-chipxenograftcolorectal cancerpharmacodynamicspharmacokineticsdrug efficacyoxaliplatinmicrofabricationmicrophysiological systembiophysical stimulibiochemical stimuliin vitro cell culturecortical neuronshippocampal neuronselectrical stimulationMicro-Electrode Arraysengineered neuronal networkspolydimethylsiloxanemicrochannelsin vivo micro bioreactoradditive manufacturingpoly-(ethylene glycol)-diacrylatebiocompatibilityCOVID-19diagnosisimage analysisPCRSARS-CoV-2MedicineCarvalho Violetaedt1302053Teixeira Senhorinha de Fátima Capela FortunasedtRibeiro JoãoedtCarvalho VioletaothTeixeira Senhorinha de Fátima Capela FortunasothRibeiro JoãoothBOOK9910639996703321Micro3026065UNINA