05987nam 2201573z- 450 991063999600332120231214132834.03-0365-6068-8(CKB)5470000001633393(oapen)https://directory.doabooks.org/handle/20.500.12854/95858(EXLCZ)99547000000163339320202301d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNatural and Synthetic Bioactives for Skin Health, Disease and ManagementBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (314 p.)3-0365-6067-X In recent years, researchers have shown a special interest in natural products as alternative methods for the prevention, treatment, and/or management of various skin illnesses and disorders, primarily due to their natural availability, efficacity, reduced cost, and minimal toxicity. In a similar vein, synthetic bioactives, as well as small molecules, have been studied in vitro, in vivo, and in clinical studies as potential drugs or supplements. This Special Issue of Nutrients comprises an array of literature reviews, original communications, and studies on the roles of natural products, synthetic bioactives, and small molecules in a variety of skin disorders and diseases, such as aging, atopic dermatitis, cutaneous T-cell lymphomas, melanoma, allergies, hyperpigmentation, inflammation, and more, which were investigated through in vitro and ex vivo approaches, preclinical trials, cell-based assays, and animal models. The mechanisms of action of certain compounds are proposed, while others are currently under investigation. The authors of the papers also explore technologies designed to improve the bioavailability and delivery of certain compounds. In lieu of ongoing research on a variety of skin disorders, the wealth of information published in this Special Issue can act as a springboard for the development of new preventive and therapeutic modalities for the management of skin diseases.Research & information: generalbicsscBiology, life sciencesbicssckeratinocytesrutinascorbic acidUV radiationproteomics3D cell cultureborage oiltriacylglycerol metabolismacyl-ceramidecorneocyte lipid envelopeepidermisanti-melanogenesisB16/F10 melanoma cellhydroxyoctadecadienoic acidSorghum bicolor3-isobutyl-1-methylxanthinemycosis fungoidesatopic dermatitiscutaneous lymphomascornified envelope proteinsFLGmicroalgaePlanktochlorella nurekisskin cellsproliferationsenescenceholothuroidsglycosaminoglycansinflammationear-inflammationwheyLactobacillus helveticusmelaninα-melanocyte-stimulating hormonetyrosinasetyrosinase-related protein 1dopachrome tautomerasemicrophthalmia-associated transcription factorcosmeticsblack cuminNigella sativaThymocid®skin agingglycationcollagencollagenaseelastasemelanogenesiscosmeceuticalkonjac glucomannanultraviolet Bhuman epidermal primary melanocyteshuman embryonic fibroblastsanti-inflammatory activityantioxidant activityCornus officinalismolecular dockinghuman high-affinity IgE receptorsα-MSHUVB irradiationlotus seedpod extractepigallocatechinpropolisskinmatrix metalloproteinase-1UVphosphoinositide 3-kinaseskin careskin healthbioactive substancesphytonutrientsantioxidantsnutraceuticalsPerilla frutescenscell proliferationultraviolet radiationDNA repairLactobacillus plantarum CJLP55acne vulgarissebumhydrationurine bacterial extracellular vesiclesfungal infectionsnanohydrogelpolysaccharideessential oilseggshell membranekeratinocyte differentiationTRPVskin thicknessLithospermum erythrorhizonNC/NgaTh1Th2Th17Th22immune balanceskin barrier functionResearch & information: generalBiology, life sciencesChamcheu Jean Christopheredt1278483Walker Anthony LedtNoubissi-Kamdem FeliciteedtChamcheu Jean ChristopherothWalker Anthony LothNoubissi-Kamdem FeliciteothBOOK9910639996003321Natural and Synthetic Bioactives for Skin Health, Disease and Management3013407UNINA