04445nam 2200757z- 450 991055738270332120220111(CKB)5400000000042072(oapen)https://directory.doabooks.org/handle/20.500.12854/76942(oapen)doab76942(oapen)76942(EXLCZ)99540000000004207220202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCellular Senescence in Health, Disease and Aging: Blessing or Curse?Basel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (112 p.)3-0365-2175-5 3-0365-2176-3 Dear Colleagues, When Hayflick and Moorhead coined the term "cellular senescence" (CS) almost 60 years ago, this phenomenon was understood as a mechanism, usually induced by activation of the DNA-repair machinery, to prevent uncontrolled proliferation. Meanwhile, additional beneficial roles for CS have been identified, such as embryonic development and wound healing. The senescence associated secretory phenotype (SASP) activated in most senescent cells (SC) signals to the immune system "come here and remove me". In organisms with young and functional immune systems, occurring SC are usually detected and removed. If SC remain in the tissue expressing the SASP, this will cause not just a damaging local inflammation but can also induce remodeling and regeneration of the surrounding tissue as well as spreading of senescence. Old organisms show reduced regenerative potential and immune function which leads to accumulation of SC. Accordingly, accumulation of SC was observed in tissues of aged individuals, but importantly also in the context of age-related disorders, neurodegenerative, or cardiovascular diseases and others. Because of its detrimental effect of the surrounding tissue, accumulation of SC is not just a consequence, but can rather been understood as a major driver of aging. In line with this, recent studies described that removal of SC showed beneficial effects on healthspan and lifespan. This exciting research led to the discovery of "senolytics", drugs which can kill SC. Given the heterogeneity of cell types that show senescence-like phenotypes, including heart muscle and post-mitotic neuronal cells, further research is required to unravel the molecular background that renders a cell type vulnerable to senesce. Additionally, it will be important to understand how senescence is cell type-specifically induced and which molecules serve as drug targets to prevent senescence and its spreading, or actively kill SC. This special issue will shed light on the molecular pathways of CS and inflammaging and on possible strategies to interfere with these processes. Dr. Markus Riessland Guest EditorCellular Senescence in Health, Disease and AgingBiology, life sciencesbicsscResearch and information: generalbicsscAIM2 inflammasomeAlzheimer's diseaseamyotrophic lateral sclerosisbiology of agingbraincancercell-cyclecellular senescencechemotherapy resistanceDNA damagegerosciencehomeostasisinflammationmelanomamild cognitive impairmentn/aneurodegenerationneuronal senescencepancreatic adenocarcinomaPOP3post-mitoticprostateregenerationsecreted protein acidic and rich in cysteinesenescencesenescence-associated secretory phenotype (SASP)senolyticsstress responsetauopathytumor infiltrationγH2AXBiology, life sciencesResearch and information: generalRiessland Markusedt1327006Riessland MarkusothBOOK9910557382703321Cellular Senescence in Health, Disease and Aging: Blessing or Curse3037786UNINA04151nam 2201237z- 450 9910639984503321202301053-0365-6223-0(CKB)5470000001633509(oapen)https://directory.doabooks.org/handle/20.500.12854/95884(oapen)95884(EXLCZ)99547000000163350920202301d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAdvanced Testing of Soft Polymer MaterialsBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (212 p.)3-0365-6224-9 Manufacturers of soft polymer products, as well as suppliers and processors of polymers, raw materials, and compounds or blends are compelled to use predictive and advanced laboratory testing in their search for high-performance soft polymer materials for future applications. The collection of 12 publications contained in this edition therefore presents different methods used to solve problems in the characterization of various phenomena in soft polymer materials, asks relevant questions and offers appropriate solutions.Research & information: generalbicsscPhysicsbicsscResearch and information: generalbicsscultraviolet radiationthermoplastic elastomerhigh vinyl S-B-Sphotoinitiatormechanical propertiesrubbercuringbismaleimidetensile strengthDiels–Alder reactioneffective electrical resistanceelastomer sensorsnatural rubberlocal strainconductive fillerdigital image correlationstrain sweeprheometerrubber process analyzerswellingabsorptioninfrared spectroscopymass spectrometrygas chromatographymechanical behaviorsynthetic aviation fuels3D printed elastomerselastomerfast characterizationenergy stored and releasedheat source reconstructionintrinsic dissipationinfrared thermographyengine mountelastomer characterisationexperimental testingresonance frequencydynamic stiffnessparameter identificationelectrodynamic shakertest benchcogging torquesynchronous machinecarbon blacktensileMullins effectPayne effectdynamic strainhysteresismaterial testingrheologyPoisson’s ratioviscoelasticityplasticizerpolaritycarbon black networksimultaneous mechanical and dielectric analysismechanical stabilityglass transitionkineticsresinBDSFDSCnanocompositescarbon nanotubesatomic force microscopydynamical mechanical analysisResearch & information: generalPhysicsResearch and information: generalStocÌŒek RadekedtHeinrich G(Gert)edtKipscholl ReinholdedtStocÌŒek RadekothHeinrich GertothKipscholl ReinholdothBOOK9910639984503321Advanced Testing of Soft Polymer Materials3015853UNINA