03832nam 22006855 450 991063539470332120251008161947.09789811978142(electronic bk.)978981197813510.1007/978-981-19-7814-2(MiAaPQ)EBC7157444(Au-PeEL)EBL7157444(CKB)25703758000041(DE-He213)978-981-19-7814-2(OCoLC)1355218110(EXLCZ)992570375800004120221213d2023 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierDiscovery of Small-Molecule Modulators of Protein–RNA Interactions for Treating Cancer and COVID-19 /by Wan Gi Byun1st ed. 2023.Singapore :Springer Nature Singapore :Imprint: Springer,2023.1 online resource (156 pages)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5061"Doctoral thesis accepted by Seoul National University, Seoul, Korea (Republic of)"Print version: Byun, Wan Gi Discovery of Small-Molecule Modulators of Protein-RNA Interactions for Treating Cancer and COVID-19 Singapore : Springer,c2022 9789811978135 1. Introduction -- 2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28–Let-7 Interaction -- 3. Discovery of Small-Molecule Modulators of Protein–RNA Interactions by Fluorescence Intensity-Based Binding Assay -- 4. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2 -- Appendix.This book describes the development of novel protein–RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein–RNA interactions to treat cancer and COVID-19. Modulating protein–RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein–RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein–RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein–RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein–RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein–RNA interactions in chemical biology and drug development.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5061BioengineeringBiotechnologyBiophysicsProtein foldingRNA interferenceBiological and Physical EngineeringChemical BioengineeringBiophysicsProtein FoldingRNA InterferenceBioengineering.Biotechnology.Biophysics.Protein folding.RNA interference.Biological and Physical Engineering.Chemical Bioengineering.Biophysics.Protein Folding.RNA Interference.362.1962414Byun Wan Gi1272792MiAaPQMiAaPQMiAaPQ9910635394703321Discovery of Small-Molecule Modulators of Protein–RNA Interactions for Treating Cancer and COVID-194164333UNINA