04398nam 22006495 450 991063403770332120251009103002.09789811971228(electronic bk.)978981197121110.1007/978-981-19-7122-8(MiAaPQ)EBC7153786(Au-PeEL)EBL7153786(CKB)25616804100041(DE-He213)978-981-19-7122-8(OCoLC)1356575649(EXLCZ)992561680410004120221208d2022 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierBiology of Vascular Smooth Muscle Vasoconstriction and Dilatation /by Yuansheng Gao2nd ed. 2022.Singapore :Springer Nature Singapore :Imprint: Springer,2022.1 online resource (422 pages)Biomedical and Life Sciences SeriesPrint version: Gao, Yuansheng Biology of Vascular Smooth Muscle Singapore : Springer,c2023 9789811971211 Architecture of the vessel wall -- Ultrastructure of vascular smooth muscle -- Vascular endothelium -- Electrical and mechanical properties of vascular smooth muscle -- Biochemistry of the contractile proteins of smooth muscle -- Metabolism of vascular smooth muscle -- Neurotransmitters -- Endothelium-derived factors -- Local metabolic factors -- Shear stress, myogenic response, and blood flow autoregulation -- Intracellular Ca2+ regulation -- Regulation of myosin light chain phosphorylation -- Cyclic AMP signaling -- Cyclic GMP signaling -- MicroRNAs and vasoreactivity -- Extracellular vesicles as unique signaling messengers -- Genetic and epigenetic modification -- Coronary vasoreactivity -- Cerebral vasoreactivity -- Pulmonary vasoreactivity -- Renal vasoreactivity -- Hypoxic vasoreactivity -- Ageing and vasoreactivity.This book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on newly identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The second edition intends to update the contents of the first edition with the latest achievements in the regulation of vascular activities from biochemical, structural, genetic, physiological, and pharmacological aspects. In addition, two new chapters related to microRNA and extracellular vesicles have been added to reflect their newly discovered important roles in vascular activities. The contraction and dilatation activities of vasculature are of fundamental importance for maintaining circulation homeostasis and adapting to physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.Biomedical and Life Sciences SeriesHuman physiologyPhysiologyInternal medicineMedicineResearchBiologyResearchHuman PhysiologyPhysiologyInternal MedicineBiomedical ResearchHuman physiology.Physiology.Internal medicine.MedicineResearch.BiologyResearch.Human Physiology.Physiology.Internal Medicine.Biomedical Research.599.0116Gao Yuansheng989761MiAaPQMiAaPQMiAaPQ9910634037703321Biology of Vascular Smooth Muscle2996350UNINA