01081nam--2200373---450-99000097617020331620050506145220.00097617USA010097617(ALEPH)000097617USA01009761720020222d1985----km-y0itay0103----baitaIT||||||||001yy"E così accettai di... giocare"Gabriele ZancaniPiacenzaBerti198593 p1 c. di tav., ill.19 cm2001Boy-scoutsDirezione spirituale369.4ZANCANI,Gabriele552876ITsalbcISBD990000976170203316II 2 1158(XIV 188)97369 LMXIVBKUMAPATTY9020020222USA011144PATTY9020020325USA01112520020403USA011740PATRY9020040406USA011707COPAT79020050506USA011452"E così accettai di... giocare"972428UNISA02059nam 2200385 450 991063398230332120230323212607.01-83969-108-5(CKB)4920000002066093(NjHacI)994920000002066093(EXLCZ)99492000000206609320230323d2021 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierEstrogen as a Contributing Factor to the Development of Lipedema /written by Sara Al-Ghadban, Mary L. Teeler and Bruce A. BunnellLondon :IntechOpen,2021.1 online resource (136 pages)1-83969-107-7 1. Introduction -- 2. Estrogens and estrogen receptors in lipedema -- 2.1 Estrogen and adipogenesis -- 2.2 Estrogen and inflammation -- 3. Potential hormonal therapy -- 4. Conclusion -- Acknowledgments -- Conflict of interest -- References.Lipedema is an underdiagnosed painful adipose tissue disorder that occurs almost exclusively in women, with onset manifesting at puberty or at times of hormonal change. Unlike many fat disorders, diet and exercise have little to no impact on the prevention or progression of this disease. Estrogens control the distribution of body fat and food intake, regulate leptin expression, increase insulin sensitivity, and reduce inflammation through signaling pathways mediated by its receptors, estrogen receptor alpha (ERα) and ERβ. This review will focus on understanding the role of estrogen in the pathogenesis of the disease and envisage potential hormonal therapy for lipedema patients.EstrogenEstrogen.573.44Al-Ghadban Sara1348886Bunnell Bruce A.Teeler Mary L.NjHacINjHaclBOOK9910633982303321Estrogen as a Contributing Factor to the Development of Lipedema3086577UNINA03463nam 2200445z- 450 991022005070332120210211(CKB)3800000000216270(oapen)https://directory.doabooks.org/handle/20.500.12854/40366(oapen)doab40366(EXLCZ)99380000000021627020202102d2016 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAdvances in the Prevention and Treatment of Inflammation-Associated Preterm BirthFrontiers Media SA20161 online resource (101 p.)Frontiers Research Topics.2-88919-968-1 After decades of intensive research and over 10,000 publications, preterm birth remains a major global obstetric healthcare problem. Each year, early birth is responsible for the deaths of more than one million infants worldwide and is a major cause of life-long disability. Preterm birth places an enormous financial burden on our healthcare systems, resulting in long-term adverse health outcomes and lost productivity for many people. Preterm birth is a syndrome, associated with several different aetiologies; hence, potential treatment strategies need to be matched to pathophysiology in order to be effective. There is now unequivocal evidence that inflammation is causally involved in a majority of spontaneous preterm deliveries. However, the triggers of inflammation, and the strategies by which it can be safely and effectively prevented and treated, remain the subject of ongoing investigation and debate. While intraamniotic infection is an important cause of inflammation-associated preterm birth, particularly in very preterm deliveries, 'sterile' inflammation is actually a more common finding associated with preterm birth. It is likely that the nature, localisation, timing and extent of the inflammatory insult all determine the obstetric outcome and degree of risk to the fetus. These factors will also influence the success of approaches that might be employed to achieve better pregnancy outcomes. Despite our increased understanding of the causes and significance of intrauterine inflammation, we have yet to translate this knowledge into effective therapeutic strategies for preventing prematurity and mitigating its consequences for the neonate. In this Research Topic we review recent progress in treating and preventing inflammation-associated preterm birth, approaching the topic from both the causal and therapeutic perspectives. With global attention increasingly focused on the need to translate knowledge discovery into clinical translation, we hope this EBook will provide a stimulating and timely discussion that will focus research and lead to improved healthcare outcomes for women and children.NeurosciencesbicsscActivation studyCognitionemotionfNIRSHemoglobinNeuroimagingPrefrontal Cortexworking memoryNeurosciencesMasataka Nobuo1954-1165448Perlovsky Leonid I.Hiraki Kazuo1963-BOOK9910220050703321Advances in the Prevention and Treatment of Inflammation-Associated Preterm Birth3552737UNINA