05149nam 2200481 450 991063393690332120230413215418.03-030-86698-X(MiAaPQ)EBC7150778(Au-PeEL)EBL7150778(CKB)25510543200041(OCoLC)1352969361(PPN)266353495(EXLCZ)992551054320004120230413d2022 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierChemistry of natural products amino acids, peptides, proteins and enzymes /V. K. Ahluwalia, Lalita S. Kumar, and Sanjiv KumarCham, Switzerland :Springer,[2022]©20221 online resource (250 pages)Includes index.Print version: Ahluwalia, V. K. Chemistry of Natural Products Cham : Springer International Publishing AG,c2022 9783030866976 Intro -- Preface -- Contents -- About the Authors -- 1 Amino Acids -- 1.1 Introduction -- 1.2 Nomenclature of Amino Acids -- 1.2.1 Representation of Amino Acids -- 1.3 Classification of Amino Acids -- 1.3.1 Coded or Primary Protein Amino Acids -- 1.3.2 Secondary and Tertiary Protein Amino Acids -- 1.3.3 Non-coded or Non-protein Amino Acids -- 1.3.4 Essential Amino Acids -- 1.4 Stereochemical Aspects of α-Amino Acids -- 1.4.1 Absolute Configuration of α-Amino Acids -- 1.4.2 Amino Acids with Two Chiral Centres -- 1.5 Physical Properties of α-Amino Acids -- 1.5.1 General Physical Properties -- 1.5.2 Acid-Base Properties of Amino Acids -- 1.5.3 Spectral Properties of α-Amino Acids -- 1.6 Chemical Reactions of Amino Acids -- 1.6.1 Reactions Due to Amino Group -- 1.6.2 Reactions Due to Carboxyl Group -- 1.6.3 Reactions Due to Both Amino and Carboxyl Groups -- 1.7 Industrial Preparation of α-Amino Acids -- 1.8 Chemical Synthesis of α-Amino Acids -- 1.8.1 Enantiomeric Resolution of α-Amino Acids -- 1.8.2 Asymmetric Synthesis of α-Amino Acids -- 1.9 Industrial Applications of α-Amino Acids -- 2 Peptides -- 2.1 Introduction -- 2.2 Structure and Classification of Peptides -- 2.2.1 Structure of Peptide Bond -- 2.2.2 Classification of Peptides -- 2.3 Nomenclature of Peptides -- 2.3.1 Representation of Peptides and Polypeptides -- 2.4 Peptide Synthesis -- 2.4.1 Protection of Amino Group -- 2.4.2 Protection of Carboxyl Group -- 2.4.3 Protection of Side Chains -- 2.4.4 Coupling Methods -- 2.5 Solid-Phase Peptide Synthesis -- 2.5.1 Solid-Phase Peptide Synthesis Using t-Boc Protection (Merrifield Approach) -- 2.5.2 Solid-Phase Peptide Synthesis Using Fmoc Protection (Sheppard's Approach) -- 2.5.3 Limitations of Solid-Phase Peptide Synthesis -- 2.6 Some Biologically Important Peptides -- 2.6.1 Oxytocin -- 2.6.2 Glutathione -- 2.6.3 Insulin -- 2.6.4 Bradykinin.2.6.5 Gramicidin S -- 3 Proteins -- 3.1 Introduction -- 3.2 Classification of Proteins -- 3.2.1 Classification on the Basis of Shape and Structure -- 3.2.2 Classification on the Basis of Products of Hydrolysis -- 3.2.3 Classification on the Basis of Biological Functions -- 3.3 Properties of Proteins -- 3.3.1 Molecular Weight -- 3.3.2 Amphoteric Nature -- 3.3.3 Solubility -- 3.3.4 Precipitation -- 3.3.5 Denaturation -- 3.3.6 Colour Reactions -- 3.4 Structural Organisation of Proteins -- 3.4.1 Covalent or Primary Structure of Proteins -- 3.4.2 Conformational Aspects of Proteins: Higher Order Structures -- 4 Enzymes -- 4.1 Introduction -- 4.2 Nomenclature and Classification of Enzymes -- 4.2.1 Systematic and Recommended Names -- 4.2.2 Classification Numbers and Code Names -- 4.3 Characteristics of Enzymes -- 4.3.1 Catalytic Power -- 4.3.2 Enzyme Specificity -- 4.3.3 Enzyme Regulation -- 4.4 Mechanism of Enzyme Action -- 4.5 Factors Affecting Enzyme Action -- 4.6 Chymotrypsin: An Enzyme in Action -- 4.6.1 Structure of Chymotrypsin -- 4.6.2 Important Amino Acid Residues of Chymotrypsin -- 4.6.3 Mechanism of Action -- 4.7 Cofactors (or Coenzymes) -- 4.7.1 Nicotinamide Adenine Dinucleotide (NAD+) and Nicotinamide Adenine Dinucleotide Phosphate (NADP+) -- 4.7.2 UDP-Glucose -- 4.7.3 Flavin Mononucleotide (FMN) and Flavin Adenine Dinucleotide (FAD) -- 4.7.4 Thiamine Pyrophosphate (TPP) -- 4.7.5 Cocarboxylase -- 4.7.6 Pyridoxal-5-Phosphate -- 4.8 Enzymes in Organic Synthesis -- 4.8.1 Enzymatic Oxidations -- 4.8.2 Enzymatic Hydroxylation -- 4.8.3 Enzymatic Hydrolysis -- 4.8.4 Enzymatic Reductions -- 4.8.5 Enzymatic Isomerisations -- 4.8.6 Pharmaceutical Applications of Enzymes -- Suggested Readings -- Glossary -- Index.Natural productsChemistry, OrganicNatural products.Chemistry, Organic.631Ahluwalia V. K.882673Kumar Lalita S.Kumar SanjivMiAaPQMiAaPQMiAaPQBOOK9910633936903321Chemistry of Natural Products2995243UNINA