03393nam 22006975 450 991063247430332120251113190606.03-031-18629-X10.1007/978-3-031-18629-5(MiAaPQ)EBC7147184(Au-PeEL)EBL7147184(CKB)25483505900041(PPN)266349560(OCoLC)1353296907(DE-He213)978-3-031-18629-5(EXLCZ)992548350590004120221125d2022 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierDNA-Encoded Libraries /edited by Andreas Brunschweiger, Damian W. Young1st ed. 2022.Cham :Springer International Publishing :Imprint: Springer,2022.1 online resource (280 pages)Topics in Medicinal Chemistry,1862-247X ;40Print version: Brunschweiger, Andreas DNA-Encoded Libraries Cham : Springer International Publishing AG,c2022 9783031186288 Includes bibliographical references.A History of Selection-Based High-Throughput Screening Technologies for Hit Identification -- Barcoding Strategies for the Synthesis of Genetically Encoded Chemical Libraries -- Advancements in DEL-Compatible Chemical Reactions -- Design Considerations in Constructing and Screening DNA-Encoded Libraries -- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries -- Selection Strategies in DNA-Encoded Libraries -- From DEL Selections to Validated Hits to Clinical Leads -- A Perspective on 30 Years of DNA-Encoded Chemistry. .This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening(HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery. The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as graduate students and scholars who are interested in this rapidly improving technology.Topics in Medicinal Chemistry,1862-247X ;40Pharmaceutical chemistryPhysical biochemistryBiologyTechniqueBiophysicsProteinsMedicinal ChemistryBiophysical ChemistryBiophysical MethodsProtein BiochemistryPharmaceutical chemistry.Physical biochemistry.BiologyTechnique.Biophysics.Proteins.Medicinal Chemistry.Biophysical Chemistry.Biophysical Methods.Protein Biochemistry.929.605615.19Brunschweiger AndreasYoung Damian W.MiAaPQMiAaPQMiAaPQBOOK9910632474303321DNA-Encoded Libraries2982337UNINA