10842nam 2200469 450 991062019730332120230309150607.03-031-05724-4(MiAaPQ)EBC7120757(Au-PeEL)EBL7120757(CKB)25188967700041(PPN)265861101(EXLCZ)992518896770004120230309d2022 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierPancreatic cancer a multidisciplinary approach /edited by Manoop S. Bhutani [and four others]Cham, Switzerland :Springer,[2022]©20221 online resource (394 pages)Print version: Bhutani, Manoop S. Pancreatic Cancer: a Multidisciplinary Approach Cham : Springer International Publishing AG,c2022 9783031057236 Includes bibliographical references and index.Intro -- Foreword: The Evolution of Pancreatic Cancer Care -- Preface -- Contents -- Contributors -- 1: Pancreatic Cancer at a Glance -- Introduction -- Incidence -- Prevalence -- Mortality -- Human Development Index -- Incidence Projections -- Mortality Projections -- Conclusion -- References -- 2: Risk Factors and Genetic Predisposition -- Smoking -- Obesity -- Alcohol -- Chronic Pancreatitis -- Family History -- Genetic Predisposition -- References -- 3: Pancreatic Cancer and Diabetes Mellitus -- Background -- Multidirectional Interaction Between DM and PDAC (Fig. 3.1) -- Pathogenesis of Glycemic Disturbance due to PDAC -- New-Onset Diabetes as a Harbinger of PDAC -- Efforts to Use NOD for Early Detection of PDAC -- Summary -- References -- 4: Pancreatic Cancer Screening -- Introduction -- Pancreatic Cancer Risk Factors -- Pancreatic Cancer Precursor Lesions -- Who Should Be Screened? -- Screening Tests -- Screening Guidelines and Strategies -- MD ANDERSON Screening Algorithm -- Benefits and Harms -- Psychological Impact of Pancreatic Cancer Screening -- Future Directions -- Conclusions -- References -- Part I: Diagnosis and Staging of Pancreatic Cancer -- 5: Diagnosis and Staging of Pancreatic Cancer: Imaging Evaluations-Pancreatic Protocol CT and MRI, PET-CT -- Computed Tomography -- CT Protocol -- Diagnosis -- Differential Diagnosis -- Staging -- Positron Emission Tomography/Computed Tomography -- PET/CT Protocol -- Diagnosis -- Staging -- Treatment Response -- Detection of Recurrent Disease -- Magnetic Resonance Imaging -- MRI Protocol -- Diagnosis -- Staging -- Assessment of Recurrent Cancer -- Conclusion -- References -- 6: Diagnosis and Staging of Pancreatic Cancer: Laparoscopy -- Introduction -- History -- Review of Contemporary Data -- Diagnostic Accuracy and Outcomes -- Cost-Effectiveness -- Principles of Management -- Indications.Preoperative Setting -- Staging Clarification Prior to Upfront Surgical Resection or Neoadjuvant Therapy -- Staging Clarification During Neoadjuvant Therapy -- Risk Stratification Prior to Surgery -- Intraoperative Setting -- Staging Clarification Immediately before Laparotomy -- Postoperative Setting -- Staging Clarification for Adjuvant Therapy -- Biospecimen Acquisition -- Technical Points -- Drawbacks -- Conclusion -- References -- 7: Diagnosis and Staging of Pancreatic Cancer: Role of Gastroenterologist: Endoscopic Ultrasound (EUS), EUS-Guided Biopsy -- Introduction -- Detection and Diagnosis -- Staging -- Management -- Adjuvant Molecular Testing -- Conclusion -- References -- 8: Diagnosis and Staging of Pancreatic Cancer: Role of Ca 19-9 in Diagnosis/Staging and Management -- References -- Part II: Management of Locally Advanced/Metastatic Disease -- 9: Management of Locally Advanced/Metastatic Disease: Medical Oncology -- Introduction -- Locally Advanced Disease -- Metastatic Disease -- Approach to LAPC at MD Anderson -- MD Anderson Approach to Metastatic Pancreatic Cancer -- Conclusion -- References -- 10: Management of Locally Advanced/Metastatic Disease: Radiation Oncology -- Introduction -- Radiation Therapy Treatment Strategies for Unresectable Disease -- Chemoradiation -- Proton and Carbon Ion Therapy -- Stereotactic Body Radiation Therapy (SBRT) -- Magnetic Resonance Linac-Based Treatment -- Treatment Planning Procedures -- Pre-simulation Instructions -- Patient Set-Up -- Image Acquisition -- Treatment Planning -- Planning Aims and Dose Constraints -- Treatment Verification -- Summary -- References -- Part III: Management of Resectable and Borderline Resectable Disease -- 11: Management of Resectable and Borderline Resectable Disease: Surgery -- Introduction -- History of Pancreatoduodenectomy -- Preoperative Management.Preoperative Period: Opportunity for Optimization -- Decision for Surgery -- Operative Steps -- Pancreatoduodenectomy -- Considerations for Vein Involvement -- Reconstruction -- Distal Pancreatectomy -- Postoperative Management -- Enhanced Recovery -- Quality Measures -- Future Directions -- References -- 12: Management of Resectable and Borderline Resectable Disease: Medical Oncology -- Introduction -- Definition of Resectability -- Adjuvant Therapy -- Borderline Resectable PDAC -- Neoadjuvant Therapy for PDAC -- Role of Neoadjuvant Chemotherapy without Radiation -- Locally Advanced PDAC -- What Is the Role of Radiotherapy in the Neoadjuvant Setting for PDAC? -- Histopathologic Assessment Following Neoadjuvant Therapy -- Tumor Surveillance in PDAC Using Circulating DNA (ctDNA) -- Neoadjuvant Therapy Followed by Metastasectomy for PDAC -- References -- 13: Management of Resectable and Borderline Resectable Disease: Radiation Oncology -- Introduction -- Indications for Radiation -- Adjuvant Radiation -- Neoadjuvant Radiation -- Definitive Radiation -- The Impact of Advanced Technologies in Radiation Delivery -- Imaging and Target Delineation -- Internal Motion Management -- Image-Guided Radiation Therapy -- MR-Linac -- Innovations in Radiation Techniques -- Intensity-Modulated Radiation Therapy -- SBRT -- Particle Beam Radiation -- Conclusions -- References -- Part IV: Endoscopic Management of Pancreatic Cancer Symptoms -- 14: Jaundice/Biliary Obstruction: ERCP/EUS BD -- Introduction -- Options for Biliary Decompression -- References -- 15: Gastric Outlet Obstruction: Antroduodenal Stenting, Venting PEG, EUS Guided Gastrojejunostomy -- Introduction -- Pathophysiology -- Diagnosis -- Principles of Management -- Surgical Gastrojejunostomy -- Enteral Stent Placement -- Technique -- Outcomes and Efficacy -- Adverse Events.Enteral Stents Versus Surgical Gastrojejunostomy -- EUS-Guided Gastroenterostomy -- Technique -- Outcomes and Efficacy -- EUS-GE Versus Surgical Gastrojejunostomy -- EUS-GE Versus Enteral Stents -- Adverse Events -- Venting Gastrostomy -- Special Considerations -- mGOO in the Post-Whipple Anatomy -- Delayed Gastric Emptying -- Summary and Management Algorithm -- References -- 16: Pain Control: Celiac Plexus Neurolysis -- Percutaneous Celiac Plexus Neurolysis -- Method -- Anterior Approach -- Posterior Approach -- Complications -- Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis -- Method -- Instruments -- Drugs -- Procedure -- Bilateral Approach (Fig. 16.1) -- Central Injection Approach (Fig. 16.2) -- Complications -- References -- Part V: Emerging Paradigms in Pancreatic Cancer -- 17: Minimally Invasive Surgical Approaches -- Introduction -- Minimally Invasive DP -- Minimally Invasive PD -- Foregut Robotic Surgery Program at MD Anderson -- Conclusion -- References -- 18: EUS-Guided Local Therapies -- Introduction -- EUS-Guided Fine Needle Injection of Anti-Tumor Agents -- EUS-Assisted Radiotherapy -- EUS-Guided Brachytherapy -- EUS-Guided Fiducial Placement -- EUS-Guided Tumor Ablation -- Conclusion -- References -- 19: Imaging-Based Biomarkers for Pancreatic Cancer -- Introduction: Different Contexts of Imaging for Pancreatic Cancer and How Imaging-Derived Biomarkers May Play a Role -- Considerations for Early Detection -- Prognostic Stratification of Tumors -- Treatment Response -- Specific Imaging Modalities -- Endoscopic Ultrasound {EUS} -- Computed Tomography (CT) -- MRI -- Artificial Intelligence -- Future Applications -- References -- 20: Liquid Biopsies in Pancreatic Cancer -- Introduction -- CTCs in Pancreatic Cancer -- Circulating Free DNA (cfDNA) and Circulating Tumor DNA (ctDNA) -- EVs -- References.21: Molecular Profiling and Precision Medicine for Pancreatic Cancer -- Introduction -- Sequencing Efforts Have Revealed Actionable Mutations -- Best Examples to Date -- BRCA1/2 (and PALB2) -- MSI-High -- NTRK -- Promising Targets -- Other DDR Mutations -- KRAS Wild Type PDAC: Mutations in BRAF, and Other Receptor Tyrosine Kinases -- Targeting the WNT Pathway: RNF43 Mutations and RSPO2/3 Fusions -- Survival Benefit-A National Registry for Precision Medicine (the Know Your Tumor Program) -- Elusive Drivers -- KRAS, TP53, CDKN2A/2B, and SMAD4 -- Immunotherapy -- Future Directions: Other Considerations and Biomarker Driven Approaches -- Concluding Remarks -- References -- 22: The Prospects of Immunotherapy in Pancreatic Cancer -- The Formation of Immune-Suppressive Microenvironment -- Tumor Cell-Intrinsic Factors -- Stroma Fibroblast -- T Lymphocytes -- Myeloid Cells -- Metabolism Environment -- Microbiome -- The Current Status and Prospect of Immunotherapy -- Immune Checkpoint Blockade -- Tumor Vaccine -- Adoptive Cell Therapy (ACT) -- Targeting TME -- Conclusion -- References -- 23: Microbiome in Pancreatic Cancer -- Introduction on Microbiome -- Microbial Biomarkers in Pancreatic Cancer -- Role of Pancreatic Microbiome in Preclinical Studies: Exploring Functional Relevance -- Ongoing Clinical Trials for Targeting the Microbiome During Cancer -- References -- 24: Early Drug Development in Pancreatic Cancer -- Introduction -- Targeting the Tumor Microenvironment -- T-Cell Checkpoint Inhibitors -- Other Immune Based Strategies -- Targeting the Stroma -- Targeting Tumor Cells -- KRAS-Based Targets -- Autophagy -- Other Targets -- Conclusions -- References -- 25: Mechanisms and Evidence on Pancreatic Cancer Prevention -- Introduction -- Metformin -- General Background and PC Risk Association -- Anti-tumoral and Immunomodulatory Mechanisms.Clinical Use and Potential for PC Prevention.PancreasCancerPancreasCancer.616.99437Bhutani Manoop S.MiAaPQMiAaPQMiAaPQBOOK9910620197303321Pancreatic Cancer2509315UNINA03082 am 2200685 n 450 9910416461503321202001202-8107-0987-410.4000/books.pumi.25208(CKB)5590000000001660(FrMaCLE)OB-pumi-25208(oapen)https://directory.doabooks.org/handle/20.500.12854/62130(PPN)249719932(EXLCZ)99559000000000166020200901j|||||||| ||| 0freuu||||||m||||txtrdacontentcrdamediacrrdacarrierVilla 4. Histoire et archéologie de l’occident musulman (viie-xve siècle) Al-Andalus, Maghreb, Sicile /Philippe SénacToulouse Presses universitaires du Midi20201 online resource (285 p.) 2-912025-76-1 Les textes figurant dans cet ouvrage constituent les actes d’une réunion internationale qui s’est déroulée à la fin du mois de septembre 2010, en Provence, à la fondation des Treilles. Ces journées regroupaient plusieurs spécialistes renommés et visaient à dresser un bilan des travaux associant histoire et archéologie depuis une trentaine d’années, tout en proposant de nouveaux thèmes de recherche. L’ensemble des contributions révèle la variété des thèmes abordés et la vitalité des enquêtes dans un espace géographique couvrant le bassin occidental de la Méditerranée. Organisée à l’initiative de Pierre Toubert (Collège de France), cette réunion a bénéficié de l’appui de la fondation des Treilles, du Framespa (UMR 5136 du CNRS) et du Labora- toire Islam médiéval (UMR 8167 du CNRS).ArchaeologyarchéologiehistoireOccident musulmanhistoireOccident musulmanarchéologieArchaeologyarchéologiehistoireOccident musulmanArcifa Lucia1256670Bagnera Alessandra826124Bresc Henri139639Canto Gracia Alberto J1298994Cressier Patrice657349Ettahiri Ahmed Saleh1298995Fili Abdallah1298996Gilotte Sophie1298997Guichard Pierre15630Gutiérrez Lloret Sonia1298998Laliena Corbera Carlos1295829Macias Santiago1298999Malpica Cuello Antonio1299000Manzano Eduardo1299001Molinari Alessandra162946Nef Annliese613076Sénac Philippe152934Van Staëvel Jean-Pierre1299002Sénac Philippe152934FR-FrMaCLEBOOK9910416461503321Villa 4. Histoire et archéologie de l’occident musulman (viie-xve siècle)3024990UNINA03986 am 2200781 n 450 9910342953303321201906122-7535-6639-910.4000/books.pur.119202(CKB)4100000009609499(FrMaCLE)OB-pur-119202(oapen)https://directory.doabooks.org/handle/20.500.12854/52335(PPN)267959281(EXLCZ)99410000000960949920191018j|||||||| ||| 0freuu||||||m||||txtrdacontentcrdamediacrrdacarrierL’Europe en conflits Les affrontements religieux et la genèse de l’Europe moderne (vers 1500-vers 1650) /Wolfgang KaiserRennes Presses universitaires de Rennes20191 online resource (448 p.) 2-7535-0656-6 À l’aube des temps modernes, l’Europe est secouée par une série d’affrontements religieux. Par routine ou par paresse, on pense en premier lieu à l’irruption de Martin Luther et des autres protagonistes de la Réforme protestante et à la scission de la chrétienté latine. Mais toute l’Europe n’est pas chrétienne : les temps modernes s’ouvrent avec l’expulsion, les conversions forcées et la persécution des juifs et des musulmans dans la péninsule Ibérique de la Reconquista. Et il y a une Europe ottomane, elle aussi pluri-religieuse. L’expérience européenne des conflits religieux se fait en outre dans un horizon global de la rencontre avec d’autres religions et civilisations où les Européens découvrent leur propre barbarie. Celle-ci s’exprime dans les atrocités des guerres civiles, des guerres de religion en France à l’action des troupes de Cromwell en Irlande. Partant de la pluralité religieuse de l’espace européen, les affrontements de la première modernité se lisent comme un douloureux processus d’apprentissage d’accepter et de gérer cette pluralité irréductible. Ainsi naît une notion et forme historique, politique et culturelle de l’Europe qui intègre dans sa constitution la conflictualité religieuse. Les contributions ici réunies analysent ce processus couvrant tout l’espace européen. Cet ouvrage est né de la collaboration d’un groupe d’historien(ne)s européen(ne)s spécialistes de ces questions et montre la richesse du paysage historiographique européen.HistoryMedieval &amp; Renaissance Studiesconflits religieuxRéformetolérance religieuseislamjudaïsmeRéformeislamconflits religieuxjudaïsmetolérance religieuseHistoryMedieval &amp; Renaissance Studiesconflits religieuxRéformetolérance religieuseislamjudaïsmeCzaika Otfried1294001Felici Lucia330224Gantet Claire1290412Greengrass Mark749323hAnnráchain Tadhg Ó1294002Hoock Jochen1294003Ibáñez José Javier Ruiz1294004Kaiser Wolfgang46538Loetz Francisca893182Murdock Graeme1294005Nijenhuis Andreas1287271Oliel-Grausz Évelyne1286069Paço David Do1287272Planas Natividad1294006Ryrie Alec850612Sieber Dominik1294007Tatarenko Laurent1287273Vincent Bernard234446Kaiser Wolfgang46538FR-FrMaCLEBOOK9910342953303321L’Europe en conflits3022856UNINA01470nam2 22003011i 450 VAN0002665720240806100332.84920041027d1925 |0itac50 baitaIT|||| |||||ˆ3: ‰Costruzioni in ferrodel prof. Otto Konigertradotta sulla 6. originale dall'ing. Vincenzo Melecon note dell'ing. prof. Paolo Boube4. ed. italianacon appendice d'aggiornamento dell'ing. Luigi Vittorio RossiMilanoVallardi1925VIII, 409, 40 p.ill.29 cm.001VAN000226262001 Trattato generale di costruzioni civilicon cenni speciali intorno alle costruzioni grandioseGustav Adolf Breymann205 4. ed. italiana210 MilanoVallardi215 8 v.ill.28 cm.3MilanoVANL000284KonigerOttoVANV022216295644BoubePaoloVANV022219MeleVincenzoVANV022217RossiLuigi VittorioVANV022218Vallardi <editore>VANV110668650ITSOL20240906RICABIBLIOTECA DEL DIPARTIMENTO DI ARCHITETTURA E DISEGNO INDUSTRIALEIT-CE0107VAN01VAN00026657BIBLIOTECA DEL DIPARTIMENTO DI ARCHITETTURA E DISEGNO INDUSTRIALE01PREST IVCb24(3a) 01 28573 20050927 Costruzioni in ferro1403233UNICAMPANIA