05210nam 2201441z- 450 991061947090332120231214133049.03-0365-5357-6(CKB)5670000000391565(oapen)https://directory.doabooks.org/handle/20.500.12854/93226(EXLCZ)99567000000039156520202210d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPig Genomics and GeneticsMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (318 p.)3-0365-5358-4 In this Special Issue, we present the state of the art in the field of pig genetics and genomics, including the identification of gene candidates linked to important pig traits and to nutritional modifications, with the aim of collecting the most recent advances. The published manuscripts focused on high-throughput methodologies, such as RNA sequencing, ATAC-seq, MACE-seq, chip-seq, and RRBS, and covered other fields of pig genetics. The pig (Sus scrofa) is the most common large mammal in the world. The Sus genus includes domestic pig and wild boar. Since the draft reference genome sequence of S. scrofa was assembled in 2012, the processes of identification of genes related to important phenotypic traits and of search of genetic markers for pig selection have been significantly refined. In addition, the newest wide-range high-throughput techniques, including microarrays, next-generation sequencing, and the recent PacBio sequencing platform providing ultra-long sequencing reads, allow identifying gene mutations and gene candidates throughout the whole genome, transcriptome, or epigenome and estimating quantitative traits important for breeding as well as the genetic backgrounds of inherited diseases.Research & information: generalbicsscBiology, life sciencesbicsscZoology & animal sciencesbicsscHMOX1 genepromotertranscriptional regulationHezuo Tibetan pigAQP3pigintramuscular fatadipogenesisproliferationlitter sizetotal number born aliveSNP (single nucleotide polymorphism)GWAS (Genome-Wide Association Studies)heat stressDurocRNA-SeqNMRmetabolomefatnessobesityextracellular matrixfat depositionlipid metabolismNGSgenetically modified pigsgenome modificationstransgenic pigsgenetic engineeringdisease modelsrecombinant proteinsxenotransplantationxenoantigencoagulation system dysregulationCRISPR/Cas9 systemnon-homologous DNA ends joining (NHEJ)TIDE analysisoff-targetskeletal muscle fibermeat qualitymetabolic diseaseslncRNARNA-seqporcine β-defensin 2CRISPR/Cas9antimicrobial peptidedisease-resistant animalsporcine alveolar macrophagesDNMT3BDNA methylationisoformTNF-αpigsfatty acids3'quant mRNA-seqnutrigenomicsTRIM26antiviral responseIFN-βpoly (I:C)VSVPRRSVseminal plasmaendometriumglobal gene expressionmicroarrayalternative splicingtranscriptproteindomainsingle nucleotide polymorphismhypothalamuspubertycircRNAspubertal genesDuroc pigsgrowth traitsweighted single-step GWASSNPgene expressioncongenital defectstranscriptomicsswineSus scrofaprecision medicinelymphatic systemwhole-genome sequencingSNP array genotypingResearch & information: generalBiology, life sciencesZoology & animal sciencesPiórkowska Katarzynaedt1291908Ropka-Molik KatarzynaedtPiórkowska KatarzynaothRopka-Molik KatarzynaothBOOK9910619470903321Pig Genomics and Genetics3022066UNINA