04594nam 2201189z- 450 991061946720332120231214132849.03-0365-5281-2(CKB)5670000000391602(oapen)https://directory.doabooks.org/handle/20.500.12854/93194(EXLCZ)99567000000039160220202210d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierBrain-Targeted Drug DeliveryMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (260 p.)3-0365-5282-0 Brain diseases currently affect one in six people worldwide; they include a wide range of neurological diseases, from Alzheimer’s and Parkinson’s diseases to epilepsy, brain injuries, brain cancer, neuroinfections, and strokes. The treatment of these diseases is complex and limited due to the presence of the blood–brain barrier (BBB), which covers the entirety of the brain. The BBB not only has the function of protecting the brain from harmful substances; it is also a metabolic barrier and a transport regulator of nutrients/serum factors/neurotoxins. Knowing these characteristics when it comes to the treatment of brain diseases makes it easier to understand the lack of efficacy of therapeutic drugs, resulting from the innate resistance of the BBB to permeation. To overcome this limitation, drug delivery systems based on nanotechnology/microtechnology have been developed. Brain-targeted drug delivery enables targeted therapy with a higher therapeutic efficacy and fewer side effects because it targets moieties present in the drug delivery systems.Technology: general issuesbicsscdrug delivery into the braintransendothelium based on receptor-mediated transcytosisimmunotherapyAlzheimer's diseaseanti-tau and anti-receptor bispecific monoclonal antibodiesAlzheimer's disease-relevant tau speciestemporal-spatial pathological Aβ and tau distributioninteractions between Aβ and tautau clearance in microgliatau clearance in neuronsliposomenanoparticleseizurelaserultrasoundnaringeninnanostructured lipid carrierintranasal deliverycentral composite rotatable designdepressionpomegranate seed oilnasal delivery systemmemory impairmentmovement impairmentdelivery to brainimproved memoryphospholipid oily gelhigh-grade gliomadiffuse midline gliomaglioblastomaIL-13Rα2IL-13immunotoxintargeted therapyGB-13IL13.E13K-PE4Ereceptor expressionacetaminophenblood-brain barrierclaudin-5CNS drug deliveryopioidstight junctionmicrodialysiscerebral open flow microperfusionelectrochemical biosensorsmacromoleculestolcaponemicroparticlesnanoparticlesPLGAParkinson's diseasenose to brain deliverygene therapypolyplexeshyaluronidaseglycol chitosanbrain cancerchemoattractantCXCLCXCRglioblastoma multiforme3D cell culture systemsnon-human primateconvection-enhanced deliveryneurosurgeryoptogeneticsblood-brain barrierbrain targeted therapydrug deliverycerebrospinal fluid microcirculationbrain biodistributionTechnology: general issuesSousa Fláviaedt1323094Sousa FláviaothBOOK9910619467203321Brain-Targeted Drug Delivery3035376UNINA