04285nam 2201213z- 450 991061946500332120231214133626.03-0365-5324-X(CKB)5670000000391624(oapen)https://directory.doabooks.org/handle/20.500.12854/93217(EXLCZ)99567000000039162420202210d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierState-of-Art in Innate ImmunityMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (188 p.)3-0365-5323-1 The innate immune system is the first line of defense against bacterial and viral infections and sterile inflammation through the recognition of pathogen-associated molecular patterns (PAMPs) by pathogen recognition receptors (PRRs) resulting in the production of proinflammatory and antiviral cytokines and chemokines. Several damage-associated molecular patterns (DAMPs), which were released by passive or active mechanisms under sterile conditions, are additionally recognized by PRRs and can cause or even aggravate the inflammatory response. In this special issue many aspects of innate immunity are summarized. Mechanisms of different DAMPs to induce pro- and anti-inflammatory activities, functions of different immune cells, as well as the crosstalk between coagulation and innate immunity were described. Furthermore, aspects of autoinflammatory diseases, types of programmed cell death pathways, and insect immunity are covered. Finally, therapeutic options for the treatment of diseases related to autoimmunity or infections are suggested. Overall, this special issue presents a broad overview of activities related to sterile inflammation and defense mechanisms of innate immunity.Medicinebicsscinflammationtype I interferonsinterleukin-1βcrosstalkhepatic non-parenchymal cellsalbuminchronic liver diseasesbacteriacytomegalovirusendothelin receptorrepurposingcell cultureDrosophila suzukiihemocytesplasmatocytesextracellular trapsHMGB1RAGETLR4DAMPSIRT1α7-nicotinic acetylcholine receptornociceptorcancerCOVID-19proteostasisautoinflammationribosomopathiesproteinopathiesproteasomopathiesextracellular RNAcytokinesmacrophagesendothelial cellstoll-like receptorsangiogenesisγδ T cellsgamma delta T cellsproliferationmacrophage polarizationneutrophilsneutrophil extracellular trapsNETsischemiaPANoptosisPANoptosomepyroptosisapoptosisnecroptosisinflammatory cell deathinflammasomeinnate immunityinfectionNLRcaspaseIRF1ZBP1RIPK1RIPK3MLKLNLRP3AIM2Pyrincaspase-1ASCcaspase-8caspase-3caspase-7plasticityredundancySMOC1thrombinMedicineFischer Silviaedt1320373Deindl ElisabethedtFischer SilviaothDeindl ElisabethothBOOK9910619465003321State-of-Art in Innate Immunity3034203UNINA