05232nam 2201513z- 450 991055780030332120210501(CKB)5400000000045400(oapen)https://directory.doabooks.org/handle/20.500.12854/68544(oapen)doab68544(EXLCZ)99540000000004540020202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierEmerging Role of Lipids in Metabolism and DiseaseBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (308 p.)3-03943-701-1 3-03943-702-X Even though initially considered as a passive means for storing energy, lipids are now regarded as multifaceted molecules with crucial structural and functional activities. For instance, some of them play essential roles as key components of cell membranes whereas others act as signaling molecules in the regulation of cell homeostasis. In recent years, lipid research has attracted increasing interest because of the involvement of this class of compounds in human health. Indeed, a plethora of pathological conditions are characterized by alterations in lipid metabolism, such as cardiovascular diseases and brain disorders. This Special Issue is a collection of papers from different experts in lipid research, with the aim of providing new insights into the physiopathological involvement of lipids and their impact on human health. This collection also demonstrates the usefulness of interdisciplinary approaches in the development of novel methods to study and manipulate lipid metabolism, which may represent an attractive target for designing effective therapeutic strategies to counteract numerous pathologies.Medicinebicsscacid sphingomyelinaseadiponectinadipose tissueangiogenesisatherosclerosisATMautotaxinBDNFBET proteinsbrainbreast cancerbreast reconstructioncardiovascular diseasecell proliferationcell signalingcholesterolCholesterolchronic inflammationdiabetes mellitusDNA damage responsedouble strand breakseicosanoidsendothelial cellepicardial fat thicknessepigeneticsepinephrinefatty acidFatty acidsfemalefrontal cortexG-protein coupled receptorsgenderglyceridehaptoglobinhigh-cholesterol diethigh-density lipoproteinhigh-sensitivity c-reactive proteinhippocampusHMGCRhyperglycemiaionizing radiationischemiaischemic strokeJQ1LDLrleptinlipidlipid dropletslipid mediatorsLipid mediatorslipid metabolismlipid metabolism diseaseslipid storage diseasesLipidslipocalinlipolysislipophagyLipophagylipoproteinsliverlysocardiolipin acyltransferaselysophosphatidic acidmetabolic reprogrammingmetabolic stressmetabolismmTORC1mutationsneutral sphingomyelinasenuclear sphingolipidsoral drug absorptionoxidative stressoxidized phospholipidsp53pathologyphosphatidylinositol 4,5-bisphosphatephospholipase A2 (PLA2)phospholipase Cphospholipase Dphospholipidpolyunsaturated fatty acidsprodrugprostaglandinspulmonary fibrosisradiationSODsphingolipidsSphingolipidssphingomyelin metabolismsphingosine kinase 1sphingosine-1-phosphateSREBPsteroidsynaptic proteinsTFEBTMEM97visceral fat thicknessMedicinePallottini Valentinaedt1309613Segatto MarcoedtPallottini ValentinaothSegatto MarcoothBOOK9910557800303321Emerging Role of Lipids in Metabolism and Disease3029453UNINA03445nam 22006013 450 991059715530332120230113084627.01-80207-904-110.3828/9781802077230(CKB)5450000000454850(MiAaPQ)EBC30202734(Au-PeEL)EBL30202734(oapen)https://directory.doabooks.org/handle/20.500.12854/92608(PPN)266300030(oapen)doab92608(EXLCZ)99545000000045485020230113d2023 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierNew Perspectives on the Medieval 'Agricultural Revolution' Crop, Stock and Furrow1st ed.LiverpoolLiverpool University Press2022Liverpool :Liverpool University Press,2023.©2023.1 online resource (308 pages)1-80207-723-5 Across Europe, the early medieval period saw the advent of new ways of cereal farming which fed the growth of towns, markets and populations, but also fuelled wealth disparities and the rise of lordship. These developments have sometimes been referred to as marking an ‘agricultural revolution’, yet the nature and timing of these critical changes remain subject to intense debate, despite more than a century of research. The papers in this volume demonstrate how the combined application of cutting-edge scientific analyses, along with new theoretical models and challenges to conventional understandings, can reveal trajectories of agricultural development which, while complementary overall, do not indicate a single period of change involving the extension of arable, the introduction of the mouldboard plough, and regular crop rotation. Rather, these phenomena become evident at different times and in different places across England throughout the period, and rarely in an unambiguously ‘progressive’ fashion. Presenting innovative bioarchaeological research from the ground-breaking Feeding Anglo-Saxon England project, along with fresh insights into ploughing technology, brewing, the nature of agricultural revolutions, and farming practices in Roman Britain and Carolingian Europe, this volume is a critical new contribution to environmental archaeology and medieval studies in England and beyond.New Perspectives on the Medieval ‘Agricultural Revolution’ New Perspectives on the Medieval ‘Agricultural Revolution’ Medieval historybicsscMedieval European archaeologybicsscLandscape archaeologybicsscEnglandbicsscc 500 CE to c 1000 CEbicsscarchaeological science; environmental archaeology; agricultural history; field systems; early medievalMedieval historyMedieval European archaeologyLandscape archaeologyEnglandc 500 CE to c 1000 CE630.940902Hamerow Helena622528McKerracher Mark1273149MiAaPQMiAaPQMiAaPQBOOK9910597155303321New Perspectives on the Medieval 'Agricultural Revolution2999783UNINA