03735ngm 2200781 a 450 991059699790332120231116231050.0(CKB)3780000000053303(UkLoHST)2897(UkLoHST)HST3818(EXLCZ)9937800000000533033818Henry Stewart Talks20141027d2014 || vengurcna|||a||||crdamediacrrdacarrierMismatch repair deficient cancers diagnosis, treatment and prevention /John BurnLondon Henry Stewart Talks20141 online resource (1 streaming video file (44 min.) color, sound)Molecular genetics of human disease,2056-452XAnimated audio-visual presentation with synchronized narration.Title from title frames.Contents: Lynch syndrome (underlying single gene defect) -- Microsatellites -- Important genes containing repeat sequences -- MSI testing (5 marker panel) -- Mismatch repair (MMR) -- The genomic pathogenesis of colorectal cancer (CRC) -- EGFR and BRAF mutant inhibition -- BRAF colon cancer project -- Methotrexate & MMR deficient tumours -- Africans & bowel cancer (Dennis Burkitt) -- Cancer prevention program (CaPP) -- NSAIDs and reduced colorectal cancer risk -- Aspirin effect on polyps in FAP and colorectal adenoma -- The prevention paradox -- CaPP2 (Colorectal & Lynch syndrome cancers) -- Meta-analysis of cancer deaths with aspirin treatment -- CRCs in people on aspirin (mostly COX2 negative) -- Individual response to aspirin in cancer prevention -- History of salicylate as an essential nutrient -- CaPP3 study -- Peptides created by slippage in microsatellite coding -- Antibodies as a possible biomarker for Lynch syndrome -- The Micoryx vaccine.Henry Stewart talks.Biomedical & life sciences collection.Molecular genetics of human disease.AspirinCancerGenetic aspectsColon (Anatomy)CancerGenetic aspectsColon (Anatomy)CancerTreatmentMedical geneticsMolecular geneticsRectumCancerGenetic aspectsRectumCancerTreatmentAspirintherapeutic useBiomarkersColorectal NeoplasmsdiagnosisColorectal NeoplasmsgeneticsColorectal NeoplasmstherapyColorectal Neoplasms, Hereditary NonpolyposisDNA Mismatch RepairGenetics, MedicalMicrosatellite InstabilityMicrosatellite RepeatsAspirin.CancerGenetic aspects.Colon (Anatomy)CancerGenetic aspects.Colon (Anatomy)CancerTreatment.Medical genetics.Molecular genetics.RectumCancerGenetic aspects.RectumCancerTreatment.Aspirintherapeutic use.Biomarkers.Colorectal Neoplasmsdiagnosis.Colorectal Neoplasmsgenetics.Colorectal Neoplasmstherapy.Colorectal Neoplasms, Hereditary Nonpolyposis.DNA Mismatch Repair.Genetics, Medical.Microsatellite Instability.Microsatellite Repeats.Burn JohnMD, MRCP.spk1739013UkLoHSTUkLoHSTVIDEO9910596997903321Mismatch repair deficient cancers diagnosis, treatment and prevention4162530UNINA