04019nam 2201045z- 450 991059507940332120220916(CKB)5680000000080731(oapen)https://directory.doabooks.org/handle/20.500.12854/92076(oapen)doab92076(EXLCZ)99568000000008073120202209d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierEnhancing Mesenchymal Stem Cells (MSCs) for Therapeutic PurposesBasel20221 online resource (204 p.)3-0365-4996-X 3-0365-4995-1 The regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have made these cells the focus of multiple pre-clinical studies and clinical trials. While the results from these clinical studies have established that MSCs are safe, the efficacy of these cells is not as well-established. In this regard, there have been increased efforts towards generating potentiated/activated MSCs with enhanced therapeutic efficacy. Research on the mechanisms for enhancing MSC potency and efficacy is an area of active study with great potential for translation into clinical settings. The purpose of this book is to bring together recent research from a broad range of topics relating to potentiation strategies for enhancing MSC therapeutic efficacy, including growth factor pre-conditioning, hypoxia, and 3D culture. The research compiled in this book increases the basic understanding of MSC culture techniques and describes some MSC preparations for potential novel therapeutic applications.Enhancing Mesenchymal Stem Cells Medicine and Nursingbicssc3-methyladenine3D cultureadipose tissue-derived stem cells (ASCs)adipose-derived stem cellAKB-6548angiogenesisastrocytesautophagyaxon growthCD206cell therapychemotaxiscombination therapyengineered cardiac patchesexosomefibroblast growth factor 2hepatocyte growth factorhypoxiaIFN-γimmunomodulationimmunosuppressioniMSC secretomeinflammationiPSC-derived MSCsliver cirrhosismacrophagesmalignant pleural mesothelioma (MPM)mesenchymal stem cellsmesenchymal stromal cellsmesotheliomananofiber-hydrogel compositeneuralneuroprotectionneurospheresosteogenic differentiationoxygen conditionsparacrine potentialphagocytosisplacenta-derived mesenchymal stem cellspluripotencypolyunsaturated fatty acidpotentiation of iMSC efficacypre-conditioningpreconditioningprimingquiescencerapamycinsecondary injurysecretomesecretory profilespheroidsspinal cord injuryumbilical cordVadadustatWharton's jelly mesenchymal stem cellsWKYMVmMedicine and NursingYlostalo Joni Hedt1289237Durand Nisha CedtYlostalo Joni HothDurand Nisha CothBOOK9910595079403321Enhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes3030230UNINA