05376nam 2201429z- 450 991059507290332120231214133423.0(CKB)5680000000080797(oapen)https://directory.doabooks.org/handle/20.500.12854/92141(EXLCZ)99568000000008079720202209d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierClinical Utility of Applying PGx and Deprescribing-Based Decision Support in PolypharmacyFuture PerspectivesBaselMDPI Books20221 electronic resource (224 p.)3-0365-5162-X 3-0365-5161-1 Polypharmacy is a necessary and important aspect of drug treatment; however, it becomes a challenge when the medication risks outweigh the benefits for an individual patient. Drug–drug interactions and the introduction of prescribing cascades are common features of polypharmacy, which can lead to ineffectiveness and increased risk of adverse drug reactions (ADR). Genes encoding CYP450 isozymes and other drug-related biomarkers have attracted considerable attention as targets for pharmacogenetic (PGx) testing due to their impact on drug metabolism and response. This Special Issue is devoted to explore the status and initiatives taken to circumvent ineffectiveness and to improve medication safety for polypharmacy patients. Specific areas include drug–drug interactions and consequences thereof in therapeutic management, including PK- and PD-profiling; the application of PGx-based guidance and/or decision tools for drug–gene and drug–drug gene interactions; medication reviews; development and application of deprescribing tools; and drivers and barriers to overcome for successful implementation in the healthcare system.Clinical Utility of Applying PGx and Deprescribing-Based Decision Support in Polypharmacy MedicinebicsscPharmaceutical industriesbicsscacute kidney injuryearly biomarkerplasma neutrophil gelatinase-associated lipocalinsoluble urokinase plasminogen activator receptormedication optimizationolder patientsemergency departmentmultimorbiditypolypharmacypotentially inappropriate medication useolder adultsprevalencedeterminantschronicoutpatient2019 Beers criteriaEthiopiapharmacogenomicspersons with diabetesdrug–drug interactionsdrug–gene interactionscytochrome P450SLCO1B1drug interaction checkersadverse drug reactionspharmacogeneticspersonalized medicinephenprocoumonDOACsbleedingthromboembolismHLAdrug hypersensitivityabacavirallopurinolflucloxacillinantiepileptic drugscost-effectivenessshared medication recordmedication reconciliationdrug information servicehospital pharmacy serviceelectronic prescribingelectronic medical recordclinical pharmacistCYP2D6CYP2D7PCYP2D8Pcopy number variationCNVgenotyping5’nuclease assayHRMhigh resolution meltingdrug metabolizationextracellular vesiclesexosomesmicrovesiclespharmacogene expressionmedication reviewdeprescriptionsquality of lifeagedaged, 80 and overnursing homesdeprescribingmedication-based risk scorehealth outcomescytochromesCYP1A2adverse drug reactionantipsychoticsolanzapineclozapineloxapinechildrenyouthdigital decision-supporthealth services researchgeneral practiceprocess evaluationantidepressantsutilitypopulation-basedappropriatenessmedication adherencedigital healthMedicinePharmaceutical industriesVermehren Charlotteedt1296269Westergaard NielsedtVermehren CharlotteothWestergaard NielsothBOOK9910595072903321Clinical Utility of Applying PGx and Deprescribing-Based Decision Support in Polypharmacy3023932UNINA05197nam 2200565 450 991079738780332120231115111842.01-61444-522-2(CKB)3710000000437116(EBL)3433713(OCoLC)914739915(SSID)ssj0001535784(PQKBManifestationID)11860460(PQKBTitleCode)TC0001535784(PQKBWorkID)11501957(PQKB)11405376(MiAaPQ)EBC3433713(Au-PeEL)EBL3433713(CaPaEBR)ebr11069790(RPAM)18532959(EXLCZ)99371000000043711620150707d2015 uy| 0engur|n|---|||||txtccrA century of advancing mathematics /Stephen F. Kennedy, editor; associate editors, Donald J. Albers [and five others][Washington, District of Columbia] :Mathematical Association of America,2015.1 online resource (0 p.)Spectrum,2638-9045 ;v. 81Description based upon print version of record.0-88385-588-7 Includes bibliographical references.A Century of Advancing Mathematics; copyright page; Contents; Preface; Part I Mathematical Developments; The Hyperbolic Revolution: From Topology to Geometry, and Back; A Century of Complex Dynamics; Map-Coloring Problems; Six Milestones in Geometry; Defying God: the Stanley-Wilf Conjecture, Stanley-Wilf Limits, and a Two-Generation Explosion of Combinatorics; What Is the Best Approach to Counting Primes?; A Century of Elliptic Curves; Part II Historical Developments; The Mathematical Association of America: Its First 100 YearsThe Stratification of the American Mathematical Community: The Mathematical Association of America and the American Mathematical Society, 1915--1925Time and Place: Sustaining the American Mathematical Community; Abstract (Modern) Algebra in America 1870--1950: A Brief Account; Part III Pedagogical Developments; The History of the Undergraduate Program in Mathematics in the United States; Inquiry-Based Learning Through the Life of the MAA; A Passport to Pleasure; Strength in Numbers: Broadening the View of the Mathematics Major; A History of Undergraduate Research in MathematicsThe Calculus Reform Movement: A Personal AccountIntroducing ex; Part IV Computational Developments; Computational Experiences in the Pre-Electronic Days; A Century of Visualization: One Geometer's View; The Future of Mathematics: 1965 to 2065; Part V Culture and Communities; Philosophy of Mathematics: What Has Happened Since Gdel's Results?; Twelve Classics People who Love Mathematics Should Know; or, ``What do you mean, you haven't read E. T. Bell?The Dramatic Life of Mathematics: A Centennial History of the Intersection of Mathematics and Theater in a Prologue, Three Acts, and an Epilogue2007: The Year of Euler; The Putnam Competition: Origin, Lore, Structure; Getting Involved with the MAA: A Path Less Traveled; Henry L. Alder; Lida K. Barrett; Ralph P. Boas; Leonard Gillman --- Reminiscences; Paul Halmos: No Apologies; Ivan Niven; George Pólya and the MAA"The MAA [Mathematical Association of America] was founded in 1915 to serve as a home for The American Mathematical Monthly. The mission of the Association--to advance mathematics, especially at the collegiate level--has, however, always been larger than merely publishing world-class mathematical exposition. MAA members have explored more than just mathematics; we have, as this volume tries to make evident, investigated mathematical connections to pedagogy, history, the arts, technology, literature, every field of intellectual endeavor. Essays, all commissioned for this volume, include exposition by Bob Devaney, Robin Wilson, and Frank Morgan; history from Karen Parshall, Della Dumbaugh and Bill Dunham; pedagogical discussion from Paul Zorn, Joe Gallian and Michael Starbird, and cultural commentary from Bonnie Gold, Jon Borwein and Steve Abbott. This volume contains 35 essays by all-star writers and expositors writing to celebrate an extraordinary century for mathematics--more mathematics has been created and published since 1915 than in all of previous recorded history. We've solved age-old mysteries, created entire new fields of study, and changed our conception of what mathematics is. Many of those stories are told in this volume as the contributors paint a portrait of the broad cultural sweep of mathematics during the MAA's first century. Mathematics is the most thrilling, the most human, area of intellectual inquiry; you will find in this volume compelling proof of that claim."--Back cover.MathematicsHistory20th centuryMathematicsHistoryKennedy Stephen F.Mathematical Association of America.MiAaPQMiAaPQMiAaPQBOOK9910797387803321A century of advancing mathematics3744584UNINA