06971nam 2202161z- 450 991059507190332120231214132837.0(CKB)5680000000080810(oapen)https://directory.doabooks.org/handle/20.500.12854/92038(EXLCZ)99568000000008081020202209d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMarine Drug Research in China: Selected Papers from the 15-NASMD ConferenceBaselMDPI Books20221 electronic resource (512 p.)3-0365-4569-7 3-0365-4570-0 The Book covers this whole field, from the discovery of structurally new and bioactive natural products (including biomacromolecules), from marine macro-/micro-organisms, to the pharmacodynamics, pharmacokinetics, metabolisms, and mechanisms of marine-derived lead compounds, both in vitro and in vivo, along with the synthesis and/or structural optimization of marine-derived lead compounds and their structure–activity relationships. Taken together, this Special Issue reprint not only provides inspiration for the discovery of marine-derived novel bioactive compounds, but also sheds light on the further research and development of marine candidate drugs.Marine Drug Research in ChinaMedicinebicsscAntarctic krill (Euphausia superba)peptideantioxidant activitystabilityoysterplasmapeptidomeantimicrobial peptidescytotoxicityactinomycetepiericidinsabsolute configurationPestalotiopsis heterocornisheterocornolsanti-inflammatory activitysponge-derived fungussclerotideslipodepsipeptideAspergillus sclerotiorumnasopharyngeal carcinomaAChE inhibitoryvascular endothelial cellflavonoidoxidized low-density lipoproteinNrf2apoptosisbutyrolactone Ifood allergymetabolismpharmacokineticsactinomycin X2microbial pigmentsdyeingsilkantibacterial propertiesPD-L1virtual screeningpharmacophore modelingADMEmolecular dynamicsxanthonesascidian-derived fungusDiaporthe sp.anti-glioma activityantiagingSonneratia apetalasignaling pathwayCaenorhabditis elegansmutantscoral-derived fungiAspergillus hiratsukaemeroterpenoidsantibacterial activitycytotoxic activitydeep-sea-derived fungusAspergillus puniceusisoquinoline alkaloidprotein tyrosine phosphatase inhibitorantibacterialAspergillus sp.geodinsemisynthesizeinsecticidal activityArca inflataantitumor peptideMAPK signalingcalmodulincolorectal cancermethicillin-resistant Staphylococcus aureusactinomycin DStreptomyces parvulusmechanismmangrove endophytic PestalotiopsisSdy-1antitumor activityWnt signalingβ-catenineremophilane sesquiterpenoidsmangrove-derived fungusPenicillium sp.Oceanapiaspongesecondary metabolitesbiological activitiesdrug designanticancercyclic pentapeptidegalaxamide analoguesskipjack tuna (Katsuwonus pelamis) muscleangiotensin-I-converting enzyme (ACE) peptidemolecular dockingnitric oxide (NO)endothelin-1 (ET-1)Trichoderma longibrachiatumsesquiterpene glycosideantimicrobial activitymarine fungiAspergillus unguisdepsidesdepsidonesosteoclast differentiationsoft-coral-derived funguspyranodipyran derivativestyrosyl DNA phosphodiesterase 1 inhibitory activitiesfluorescent propertiesbutenolidesenantiomersAspergillus terreuspancreatic lipaseNAFLDfucoxanthinadenosine monophosphate-activated protein kinase (AMPK)nuclear factor erythroid-2-related factor 2-mediated (Nrf2)Toll-like receptor 4-mediated (TLR4)Aspergillus flavipes HN4-13emodinmacroporous resin XAD-16adsorption kinetics and isothermsenrichmenttetramic acid derivativesdeep-sea fungusclavipitacaeLecanicillium fusisporumchronic kidney diseasefucoidancognitive dysfunctionneuroinflammationoxidative stressGSK3β-Nrf2-HO-1 signalingmicroglial polarizationdeep-sea actinomycetesaromatic acidsoximesantihyperlipidemicphycocyaninmicrobiotatranscriptomeIL-17 pathwayHahellaprodigininechejuenlidegenome miningLC-MS/MSCDK4/6marine compoundspharmacophore constructionADMETmm-pbsaMedicineZhou Xuefengedt845353Luo XiaoweiedtLiu YonghongedtZhou XuefengothLuo XiaoweiothLiu YonghongothBOOK9910595071903321Marine Drug Research in China: Selected Papers from the 15-NASMD Conference3014644UNINA