04512nam 2201261z- 450 991059506920332120231214133204.0(CKB)5680000000080839(oapen)https://directory.doabooks.org/handle/20.500.12854/92104(EXLCZ)99568000000008083920202209d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAnticancer InhibitorsBaselMDPI Books20221 electronic resource (216 p.)3-0365-4920-X 3-0365-4919-6 The word "cancer" is associated with at least 100 different pathologies, depending on the organ involved and the type of tumor developed. Cancer is a complex disease involving multiple pathogenetic mechanisms. Characterization of different types of cancers, which distinguishes them from healthy cells and other cancers, allows for the identification of specific targets for each individual tumor. The principle of chemotherapy is based on interference with the mechanisms that regulate the life and proliferation of cancer cells, causing their death. In recent years, there has been continuous progress in the development of therapeutic agents against cancer, which is ongoing.The Anticancer Inhibitors Special Issue focuses on new target-based anticancer agents that inhibit a specific target involved in the suppression of various types of cancer and the control of their chemoresistance.There is a collection of research and review articles on advances in drug discovery, design, and development of new inhibitor compounds with potency against various cancer types.Research & information: generalbicsscChemistrybicsscbreast cancertamoxifenLY294002synergismapoptosiscell cycletea (Camellia sinensis) flowersBTFSA2780/CP70 ovarian cancer cellsS phase cell cycle arrestnicotinamide phosphoribosyltransferaseNAD+ biosynthesisinhibitorazacyclohexaneanticancer drugdrug designenthalpy effectNSCLCCathepsin Kcell proliferationcell migrationcell invasionmTORisatin-hydrazonescytotoxicityCDK2 inhibitorATP competitive inhibitorADME analysisreceptor tyrosine kinasesprotein-protein interactionsprotein engineeringdirected evolutionangiogenesisbinding affinityagonistic activitysaponinsphytochemicalstea (Camellia sinensis) flowerovarian cancerautophagyZMYND8tumorigenesisepigenetic regulationpro-oncogenic effectstumor suppressiontacrine-coumarin derivativesDNAtopoisomerases I, IIlung carcinoma cellsA549chemotherapyprodrugdrug targetingoverexpressed enzymesADCADEPTGDEPTLEAPTPROTACcyclin-dependent kinasecancerresistancesmall molecule inhibitorsPROTACsstatinspancreatic cancerDNA microarraypitavastatincerivastatinsimvastatinfluvastatinatorvastatinpravastatinHMG-CoA reductase inhibitorsResearch & information: generalChemistryFantacuzzi Marialuigiaedt1332307Ammazzalorso AlessandraedtFantacuzzi MarialuigiaothAmmazzalorso AlessandraothBOOK9910595069203321Anticancer Inhibitors3040809UNINA