04332nam 22006615 450 991059008040332120251009100335.09783031054600(electronic bk.)978303105459410.1007/978-3-031-05460-0(MiAaPQ)EBC7078092(Au-PeEL)EBL7078092(CKB)24748086700041(PPN)264191757(DE-He213)978-3-031-05460-0(OCoLC)1344015308(EXLCZ)992474808670004120220827d2022 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierUnderstanding PTMs in Neurodegenerative Diseases /edited by Victor Corasolla Carregari1st ed. 2022.Cham :Springer International Publishing :Imprint: Springer,2022.1 online resource (150 pages)Proteomics, Metabolomics, Interactomics and Systems Biology,2730-6224 ;1382Print version: Corasolla Carregari, Victor Understanding PTMs in Neurodegenerative Diseases Cham : Springer International Publishing AG,c2022 9783031054594 Includes bibliographical references and index.Protein extraction and sample preparation methods for shotgun proteomics with central nervous system cells and brain tissue -- Phosphopeptide enrichment techniques: a pivotal step for phosphoproteomic studies -- Post-Translational Modifications during Brain Development -- Aberrant protein glycosylation in brain cancers, with emphasis on glioblastoma -- Post-Translational Modification in Muscular Dystrophies -- Post-translational Modifications in Parkinson’s Disease -- Histone Modifications in Neurological Disorders -- Mitochondrial dysregulation and the influence in neurodegenerative diseases -- PTMs: A missing piece for schizophrenia studies -- Post-Translational Modifications in Brain Diseases: A Future for Biomarkers -- Index.This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs. .Proteomics, Metabolomics, Interactomics and Systems Biology,2730-6224 ;1382Post-translational modificationBioinformaticsMolecular biologyNervous systemDiseasesPost-translational ModificationsComputational and Systems BiologyMolecular BiologyNeurological DisordersPost-translational modification.Bioinformatics.Molecular biology.Nervous systemDiseases.Post-translational Modifications.Computational and Systems Biology.Molecular Biology.Neurological Disorders.612.39616.80471Carregari Victor CorasollaMiAaPQMiAaPQMiAaPQ9910590080403321Understanding PTMs in Neurodegenerative Diseases4385845UNINA