06338nam 2201633z- 450 991058594620332120220812(CKB)5600000000483014(oapen)https://directory.doabooks.org/handle/20.500.12854/91239(oapen)doab91239(EXLCZ)99560000000048301420202208d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierLeaders in Cardiovascular Research: A Special Issue Dedicated to Professor Adriana Gittenberger-De GrootBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (372 p.)3-0365-4047-4 3-0365-4048-2 The arterial pole is one of the most complex parts of the heart both in development and disease. It involves the collaboration and orchestration of contributions from the first and second heart fields as well as the neural crest. The precursor cells differentiate into endocardial cushions and putative cardiac valves, the myocardium, and epicardium of the heart, but also into the different layers of the main arterial vessels. These include not only the aorta and the pulmonary trunk but also the pulmonary and coronary arteries, and during development, the arterial duct. Many transcriptional and signaling networks act in timely concert to acquire the proper asymmetric development and function and pressure and flow dynamics. This is not only a human or even mammalian 'enterprise,' but is also taking place in so-called ancestral forms from fish to reptiles, including birds. In humans, it is small wonder that many clinical syndromes may arise when something in this complexity is amiss. This Special Issue of JCDD contains contributions focussed on the heart fields, congenital cardiac malformations and associated syndromes, with special emphasis on the cardiac outflow tract. The Issue is devoted to Prof. Dr. Adriana Gittenberger-de Groot, who dedicated her extensive career to research on cardiovascular development.Leaders in Cardiovascular ResearchPublic health and preventive medicinebicsscacute aortic syndromeanomalous left subclavian arteryaortaaortic regurgitationaortic stenosisaortic surgeryaortic valve replacementaortic wallarrhythmogenic right ventricular dysplasiaarteria lusoriaarterial ductarterial switch operationasymptomaticatrioventricular valveBentallbicuspid aortic valvecandidate genescardiac developmentcardiac fieldscardiac progenitor cellscardiomyocytecardiovascular developmentcardiovascular diseasecardiovascular pathogenesiscartilagecell identitycell polaritycleft palatecompact myocardiumcongenital heart defectscongenital heart diseasecoronary arteriescoronary arterycoronary artery anatomycoronary complicationscushiondevelopmental biologydiscordant phenotypedissection of ductus arteriosusDNA methylationductus arteriosusearly surgeryendocardial cushionsendocardial fibro-elastosisendocardiumepicardiumepigeneticsesophageal compressionfetal aortic stenosisforamen of Panizzafree edge foldinggeneticsheart tubehomograftimagingKommerell's diverticulumlateral cushionleft aortaLeiden Convention coronary coding systemlineage tracingLipton classificationloeys dietz syndrome-5major cushionmonozygotic twinsmyofibroblastsmyxomatous degenerationneointimaneural crestneural crest celloriginal leafletoutflow tractoutflow tract septationpharyngeal arch arteriespharyngeal arch arterypharyngeal ectodermpostmortem histologyprenatal ultrasoundprogenitor specificationproliferationpulmonary trunkRac1remodelingrienhoff syndromeright aortaright sided aortic archsecond heart fieldsemilunar valvessignaling networkssingle coronary arteryspeckle tracking analysissudden unexpected intrauterine deathsuperimposed tissuesurgicalTetralogy of Fallottrabeculationtracheal compressiontranscription factor AP-2αtranscriptometransforming growth factor beta-3transposition great arteries coronary anatomytransposition of the great arteriestunica mediavalvevariationswatchful waitingPublic health and preventive medicineJongbloed Moniqueedt1329049Poelmann RobertedtJongbloed MoniqueothPoelmann RobertothBOOK9910585946203321Leaders in Cardiovascular Research: A Special Issue Dedicated to Professor Adriana Gittenberger-De Groot3039270UNINA