03803nam 2201009z- 450 991058594410332120220812(CKB)5600000000483037(oapen)https://directory.doabooks.org/handle/20.500.12854/91229(oapen)doab91229(EXLCZ)99560000000048303720202208d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierIn Vitro and In Vivo Models of Colorectal Cancer for Clinical ApplicationBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (222 p.)3-0365-3966-2 3-0365-3965-4 The Special Issue "In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application", edited by Marta Baiocchi and Ann Zeuner for Cancers, collects original research papers and reviews, depicting the current state and the perspectives of CRC models for preclinical and translational research. Original research papers published in this issue focus on some of the hottest topics in CRC research, such as circulating tumor cells, epigenetic regulation of stemness states, new therapeutic targets, molecular CRC classification and experimental CRC models such as organoids and PDXs. Additionally, four reviews on CRC stem cells, immunotherapy and drug discovery provide an updated viewpoint on key topics linking benchtop to bedside research in CRC.Biology, life sciencesbicsscMicrobiology (non-medical)bicsscResearch & information: generalbicssc3D bioprintinganimal modelscancer stem cell methodscancer stem cellscancer-on-chipCDX2chromosomal instabilitycirculating tumor cellsclinical translation studyclinical trialscolon cancercolorectal cancercolorectal carcinomaCRCCTC clusterdecitabineDNA damageDNA methylationdrug combinationdrug resistanceepithelial mesenchymal transitionHIF-1αhistological examinationhypoxiaimmunofluorescence analysisimmunotherapyin vitro culturemachine learningmethodsmutation analysisorganoidspatient-derived cancer modelspatient-derived tumor organoidpatient-derived xenograftPDX modelprecision medicineprognosisradiation responserectal cancerSATB2ScreenCell®sequential filtrationsingle-cell RNA-sequencingsize-based methodtargeted therapytranscriptional programstumor cell differentiationtumor heterogeneitytumor metabolismtumor-initiating cellsBiology, life sciencesMicrobiology (non-medical)Research & information: generalBaiocchi Martaedt1318513Zeuner AnnedtBaiocchi MartaothZeuner AnnothBOOK9910585944103321In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application3033349UNINA