03786nam 2200997z- 450 991058594410332120231214133037.0(CKB)5600000000483037(oapen)https://directory.doabooks.org/handle/20.500.12854/91229(EXLCZ)99560000000048303720202208d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierIn Vitro and In Vivo Models of Colorectal Cancer for Clinical ApplicationBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (222 p.)3-0365-3966-2 3-0365-3965-4 The Special Issue "In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application", edited by Marta Baiocchi and Ann Zeuner for Cancers, collects original research papers and reviews, depicting the current state and the perspectives of CRC models for preclinical and translational research. Original research papers published in this issue focus on some of the hottest topics in CRC research, such as circulating tumor cells, epigenetic regulation of stemness states, new therapeutic targets, molecular CRC classification and experimental CRC models such as organoids and PDXs. Additionally, four reviews on CRC stem cells, immunotherapy and drug discovery provide an updated viewpoint on key topics linking benchtop to bedside research in CRC.Research & information: generalbicsscBiology, life sciencesbicsscMicrobiology (non-medical)bicssccolorectal cancerorganoids3D bioprintingpatient-derived xenograftcancer-on-chipdrug combinationcancer stem cellsdrug resistanceclinical trialstumor-initiating cellstumor heterogeneitypatient-derived cancer modelssingle-cell RNA-sequencingtumor metabolismtranscriptional programstumor cell differentiationimmunotherapymethodschromosomal instabilityDNA damagetargeted therapydecitabinecolon cancerDNA methylationclinical translation studymachine learningpatient-derived tumor organoidprecision medicineradiation responserectal cancerPDX modelCRCmutation analysishistological examinationanimal modelsin vitro culturecancer stem cell methodsSATB2colorectal carcinomaprognosisCDX2circulating tumor cellsCTC clustersize-based methodScreenCell®epithelial mesenchymal transitionhypoxiaHIF-1αimmunofluorescence analysissequential filtrationResearch & information: generalBiology, life sciencesMicrobiology (non-medical)Baiocchi Martaedt1318513Zeuner AnnedtBaiocchi MartaothZeuner AnnothBOOK9910585944103321In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application3033349UNINA