02483nam 2200409 450 991058350010332120180911110645.00-08-102355-31-78548-265-3(CKB)4100000002037915(MiAaPQ)EBC5245949(PPN)233899650(EXLCZ)99410000000203791520180220h20182018 uy 0engurcnu||||||||rdacontentrdamediardacarrierLong non-coding RNA the dark side of the genome /Antonin MorillonLondon, [England] ;Oxford, England :ISTE Press :Elsevier,2018.©20181 online resource (173 pages)Includes bibliographical references and index.Foreword -- Preface -- Non-coding RNA, its history and discovery timeline -- Definition and families of long non-coding RNA -- Biological functions of long non-coding RNA -- Non-coding RNA in development -- Long non-coding RNA and cancer -- Concluding perspectives."The dark side of the genome represents vast domains of the genome that are not encoding for proteins--the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. Here, we review this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles. We develop the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, we illustrate the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms."--Page 4 of cover.Non-coding RNALaboratory manualsNon-coding RNA572.88Morillon Antonin988949MiAaPQMiAaPQMiAaPQBOOK9910583500103321Long non-coding RNA2261525UNINA