04816oam 2200481 450 991058338810332120190911100031.00-12-802052-00-12-802025-3(OCoLC)956735866(MiFhGG)GVRL9JUC(EXLCZ)99371000000067370820160810h20162016 uy 0engurun|---uuuuardacontentrdamediardacarrierClinical challenges in therapeutic drug monitoring special populations, physiological conditions, and pharmacogenomics /edited by William Clarke, PhD, MBA, Associate Professor of Pathology, Johns Hopkins University, Baltimore, MD, Amitava Dasgupta, Professor of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, TXAmsterdam :Elsevier,[2016]�20161 online resource (xvi, 360 pages) illustrations (some color)Gale eBooksDescription based upon print version of record.Includes bibliographical references at the end of each chapters and index.Front Cover; Clinical Challenges in Therapeutic Drug Monitoring; Copyright Page; Contents; List of Contributors; Preface; 1 Overview of Therapeutic Drug Monitoring; 1.1 Introduction; 1.2 Principles of TDM; 1.3 Clinical Areas in Which TDM is Routine Practice; 1.3.1 Epilepsy; 1.3.2 Organ Transplantation; 1.3.3 Cardiology (Antiarrhythmic Drugs); 1.3.4 Psychiatry; 1.3.5 Infectious Disease; 1.3.6 Oncology; 1.4 Conclusions; References; 2 Immunoassays and Issues With Interference in Therapeutic Drug Monitoring; 2.1 Introduction; 2.2 Immunoassay Platforms Used in TDM2.3 Interference of Bilirubin, Hemolysis, and Lipemia2.4 Interferences in Digoxin Immunoassays; 2.4.1 DLIS Interferences in Digoxin Immunoassays; 2.4.2 Effect of Digibind and DigiFab on Digoxin Immunoassays; 2.4.3 Potassium-Sparing Diuretics and Digoxin Immunoassays; 2.4.4 Herbal Supplements and Digoxin Immunoassays; 2.5 Issues of Interferences With Immunoassays for Immunosuppressants; 2.5.1 Metabolite Interferences in Cyclosporine Immunoassays; 2.5.2 Metabolite Interferences in Tacrolimus Immunoassays; 2.5.3 Metabolite Interferences in Sirolimus and Everolimus Immunoassays2.5.4 Metabolite Interferences in Mycophenolic Acid Immunoassays2.6 Interferences in Immunoassays for Anticonvulsants; 2.6.1 Interferences in Phenytoin Immunoassays; 2.6.2 Interferences in Carbamazepine Immunoassays; 2.6.3 Interferences in Phenobarbital and Valproic Acid Immunoassays; 2.6.4 Interferences in Immunoassays for Newer Anticonvulsants; 2.7 Interferences in Immunoassays for TCAs; 2.7.1 Interference of Phenothiazines and Their Metabolites in Immunoassays for TCAs; 2.7.2 Interference of Carbamazepine in Immunoassays for TCAs2.7.3 Interference of Cyproheptadine and Quetiapine With Immunoassays for TCAs2.7.4 Interference of Miscellaneous Drugs With Immunoassays for TCAs; 2.8 Conclusions; References; 3 Application of Chromatography Combined With Mass Spectrometry in Therapeutic Drug Monitoring; 3.1 Introduction; 3.2 Liquid Chromatography; 3.3 Mass Spectrometry; 3.3.1 Ion Source; 3.3.2 Mass Analyzers; 3.3.2.1 Quadrupole Analyzers; 3.3.2.2 Ion Trap Analyzers; 3.3.2.3 TOF Analyzers; 3.3.3 Detectors; 3.4 Preanalytical Stage; 3.5 Application of LC-MS/MS Methods in TDM; 3.5.1 Immunosuppressants; 3.5.2 Anticonvulsants3.5.3 Antidepressants3.5.4 Antifungal Drugs; 3.5.5 Others Drug Classes; 3.6 LC-MS/MS Limitations; 3.7 Conclusions; References; 4 Monitoring Free Drug Concentration: Clinical Usefulness and Analytical Challenges; 4.1 Introduction; 4.2 Drug-Protein Binding; 4.3 Drugs Requiring Free Drug Monitoring; 4.4 Conditions in Which Monitoring Free Anticonvulsants is Necessary; 4.4.1 Clinical Utility of Monitoring Free Phenytoin Concentrations; 4.4.2 Clinical Utility of Monitoring Free Valproic Acid Concentration; 4.4.3 Clinical Utility of Monitoring Free Carbamazepine Concentrations4.5 Mechanisms of Elevated Free Anticonvulsant Levels in Various Pathophysiological ConditionsThis guide surveys critical issues in therapeutic drug monitoring for non-toxicologists who want to gain greater insight into the unique requirements of special populations and learn how to avoid drug toxicity within a narrow therapeutic window.Drug monitoringDrug monitoring.615.7Clarke WilliamDasgupta Amitava1958-MiFhGGMiFhGGBOOK9910583388103321Clinical challenges in therapeutic drug monitoring1946724UNINA