03523nam 2200469 450 991058335220332120200827201556.00-444-63720-6(CKB)3710000000951574(CaSebORM)9780444637208(MiAaPQ)EBC4744498(PPN)199243808(EXLCZ)99371000000095157420161122h20172017 uy| 0engurcnu||||||||rdacontentrdamediardacarrierAdvanced machining processes of metallic materials theory, modelling, and applications /Wit Grzesik, Professor of Mechanical Engineering, Faculty of Mechanical Engineering, Opole University of Technology, PolandSecond edition.Amsterdam :Elsevier,[2017]©20171 online resource (610 pages) illustrations0-444-63711-7 Includes bibliographical references and index.Advanced Machining Processes of Metallic Materials: Theory, Modelling and Applications, Second Edition, explores the metal cutting processes with regard to theory and industrial practice. Structured into three parts, the first section provides information on the fundamentals of machining, while the second and third parts include an overview of the effects of the theoretical and experimental considerations in high-level machining technology and a summary of production outputs related to part quality. In particular, topics discussed include: modern tool materials, mechanical, thermal and tribological aspects of machining, computer simulation of various process phenomena, chip control, monitoring of the cutting state, progressive and hybrid machining operations, as well as practical ways for improving machinability and generation and modeling of surface integrity. This new edition addresses the present state and future development of machining technologies, and includes expanded coverage on machining operations, such as turning, milling, drilling, and broaching, as well as a new chapter on sustainable machining processes. In addition, the book provides a comprehensive description of metal cutting theory and experimental and modeling techniques, along with basic machining processes and their effective use in a wide range of manufacturing applications. The research covered here has contributed to a more generalized vision of machining technology, including not only traditional manufacturing tasks, but also potential (emerging) new applications, such as micro and nanotechnology. Includes new case studies illuminate experimental methods and outputs from different sectors of the manufacturing industry Presents metal cutting processes that would be applicable for various technical, engineering, and scientific levels Includes an updated knowledge of standards, cutting tool materials and tools, new machining technologies, relevant machinability records, optimization techniques, and surface integrityMetal-cuttingMetal-cutting toolsMetal-cuttingData processingMetal-cutting.Metal-cutting tools.Metal-cuttingData processing.671.35Grzesik Wit878249MiAaPQMiAaPQMiAaPQBOOK9910583352203321Advanced machining processes of metallic materials1960608UNINA05456nam 22006735 450 991029831170332120200707005835.03-319-05134-210.1007/978-3-319-05134-5(CKB)3710000000105686(EBL)1731029(OCoLC)885122340(SSID)ssj0001199636(PQKBManifestationID)11806845(PQKBTitleCode)TC0001199636(PQKBWorkID)11214676(PQKB)10806846(MiAaPQ)EBC1731029(DE-He213)978-3-319-05134-5(PPN)178317845(EXLCZ)99371000000010568620140422d2014 u| 0engur|n|---|||||txtccrMicroRNA Targeted Cancer Therapy /edited by Fazlul H. Sarkar1st ed. 2014.Cham :Springer International Publishing :Imprint: Springer,2014.1 online resource (349 p.)Description based upon print version of record.3-319-05133-4 Includes bibliographical references and index.Preface -- The therapeutic role of microRNAs in human gliomas -- miRNA expression and functions in glioma and glioma stem cells -- The role of miRNAs in lung cancer drug resistance and targeted therapy -- The Potential Role of MicroRNA-Based Therapy for Lung Cancer Stem Cells -- State of our knowledge on miRNA targeted therapy in Lung Cancer -- miRNA-based Ovarian Cancer Diagnosis and Therapy -- Application of microRNA in the treatment and diagnosis of cervical cancer -- Overcoming Drug Resistance in Colorectal Cancer by microRNAs -- MicroRNAs as novel targets in liver cancer- facing the clinical challenge -- MicroRNA based therapeutic strategies for cancer: Emphasis on advances in renal cell carcinoma -- Modulating microRNA expression for the therapy of pancreatic cancer -- MicroRNA targeted therapy for overcoming drug resistance, reversal of EMT and elimination of cancer stem cells in prostate and pancreatic cancer.- Modulation of deregulated miRNAs for targeted therapy in thyroid cancer -- miRNA-targeted therapies in the most prevalent pediatric solid tumors -- Targeting Immune System Through Targeting miRNA For Cancer Therapy.- miRNA regulation of DNA damage repair proteins in cancer cells: interplay of ATM, TRAIL and miRNA -- miRNA regulation of VEGF/VEGFR signaling -- Systems Biology Approaches in the Design of Effective miRNA-Targeted Therapeutics. Index.Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes, and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs), and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy”, and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.CancerResearchLife sciencesMedicineCancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Science, Humanities and Social Sciences, multidisciplinaryhttps://scigraph.springernature.com/ontologies/product-market-codes/A11007Life Sciences, generalhttps://scigraph.springernature.com/ontologies/product-market-codes/L00004Medicine/Public Health, generalhttps://scigraph.springernature.com/ontologies/product-market-codes/H00007CancerResearch.Life sciences.Medicine.Cancer Research.Science, Humanities and Social Sciences, multidisciplinary.Life Sciences, general.Medicine/Public Health, general.50570610614.5999Sarkar Fazlul Hedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298311703321MicroRNA Targeted Cancer Therapy2544729UNINA