02726nam 2200433 450 991058332440332120230806023029.00-08-103019-3(CKB)4100000011392606(MiAaPQ)EBC6315971(Au-PeEL)EBL6315971(NjHacI)994100000011392606(EXLCZ)99410000001139260620230806d2020 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierApproaches to the purifacation, analysis and characterization of antibody-based therapeutics /edited by Allan Matte [and seven others]Amsterdam, Netherlands :Elsevier Limited,[2020]©20201 online resource (224 pages)Includes bibliographical references and index.1. Overview of therapeutic antibodies; 2. Platform purification approaches; 3. Strategies in the context of mAb downstream process development; 4. Process-scale purification of antibody therapeutics; 5. Process analytics for mAb purification and process development; 6. Automation approaches for small-scale mAb purification and assay development; 7. Glycan characterization of therapeutics mAbs; 8. Characterization of therapeutic antibodies using mass spectrometry; 9. Antibody binding studies using surface plasmon resonance and bio-layer interferometry methods; 10. Higher-order structure characterization methods; 11. Conformational and colloidal stability analysis of mAbs; 12. Future trends and opportunities.Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book.Antibody-drug conjugatesImmunoglobulinsAntibody-drug conjugates.Immunoglobulins.615.36Mattee AllanMiAaPQMiAaPQMiAaPQBOOK9910583324403321Approaches to the purifacation, analysis and characterization of antibody-based therapeutics3420554UNINA