10825oam 22005533 450 991058332430332120240506025530.0(CKB)3840000000209589(PPN)226416429(FR-PaCSA)88849412(MiAaPQ)EBC4932648(FRCYB88849412)88849412(EXLCZ)99384000000020958920231211d2017 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierNitric Oxide Biology and Pathobiology3rd ed.San Diego :Elsevier Science & Technology,2017.©2017.1 online resource (436 pages)9780128043196 0128043199 9780128042731 0128042737 Cover -- Title Page -- Copyright Page -- Contents -- Contributors -- Introduction and Overview -- Chapter 1 - A Concise History of the Discovery of Mammalian Nitric Oxide (Nitrogen Monoxide) Biogenesis -- Introduction -- NO and NOx Prior to 1986 -- Ancient Human/NOx, NO Relationships -- The Discovery of NO and 19th-Century Studies -- 20th-Century NO Prior to 1986 -- 1986-88: Convergence of the Discovery of Endogenous NO in the Immune, Cardiovascular, and Nervous Systems -- NO in the Immune System Prior to 1986-88 -- NO in the Cardiovascular System Prior to 1986-88 -- NO in the Nervous System Prior to 1986-88 -- The Convergence: 1986-88 -- Conclusions -- References -- Chapter 2 - An Integrated View of the Chemical Biology of NO, CO, H2S, and O2 -- Introduction -- Nitric Oxide -- Carbon Monoxide -- Hydrogen Sulfide -- Dioxygen -- Superoxide -- Hydrogen Peroxide -- Hydroxyl Radical -- Chemical Biology of NO, CO, H2S, and O2 Interactions -- Interactions at Metal Centers: Heme Proteins -- The Effect of O2 and Derived Species on the Chemical Biology of NO, CO, and H2S -- Interaction of NO and H2S -- Thiols/Thiol Proteins and NO, CO, O2, and H2S Chemical Biology -- Summary -- References -- Chapter 3 - Detection of Nitric Oxide and Peroxynitrite in Biological Systems: A State-of-the-Art Review -- Detection of Nitric Oxide -- Introduction -- Detection of Nitrate and Nitrite -- Griess Reaction -- Chemiluminescence Detection of Nitrite/­Nitrate -- Other Methods for Nitrite/Nitrate -- Probes for NO Detection -- Nitronyl Nitroxides -- Iron Dithiocarbamates -- Diaminofluorescein (DAF) -- S-Nitrosothiol Detection -- Detection of Liberated Nitrogen Oxides From S-Nitrosothiols -- Saville Reaction -- Chemiluminescence -- Detection of Protein S-Nitrosothiols -- Biotin Switch Assay -- Other Methods -- Detection of Peroxynitrite Using Boronate-Based Probes.Introduction -- Oxidation of Boronates by Peroxynitrite and Other Biologically Relevant Oxidants -- Free Radical Pathway for the Reaction Between Boronates and ONOO− -- Real-Time Monitoring of ONOO− Formed In Situ in Cell-Free Systems -- Differentiation Between Different Oxidants Using Boronic Probes -- Detection of Peroxynitrite in Cellular ­Systems -- Perspectives for In Vivo Detection of Peroxynitrite -- Acknowledgment -- References -- Chapter 4 - S-Nitrosothiols and Nitric Oxide Biology -- Introduction -- RSNO Biochemistry: How Do RSNOs Relate to NO -- S-Nitrosothiol Levels and Targets In Vivo -- SNO Antibody -- RSNO Metabolism -- RSNO Formation -- Transnitrosation -- Denitrosation -- RSNO Transport -- Emerging Modulators of RSNO: Hydrogen Sulfide and Reactive Sulfur Species -- Biological Effects of RSNOs-Evidence and Interpretation -- RSNO Therapeutics -- RSNO as NO Donors -- Summary -- References -- Chapter 5 - Cooperative Interactions Between NO and H2S: Chemistry, Biology, Physiology, Pathophysiology -- Chemical Aspects of the NO/H2S Cross-Talk -- Introduction -- Basic Chemical Properties of Sulfide as Compared to NO -- Bioactive Intermediates of the Reaction Between NO and Sulfide (and its Various Metabolites): S/N Hybrid Molecules and Poly... -- HSNO/ONS− -- ONSS− -- Polysulfides -- SULFI/NO -- Regulation of NOS Activity by H2S -- Regulation of PIP3/AKT/eNOS by Sulfide -- Regulation of eNOS Activity Via H2S-Mediated Sulfhydration -- Inhibitory Effect of H2S on NOS Activity -- Inhibitory Effect of NO on CBS Activity -- Regulation of NOS Expression by H2S -- Regulation of eNOS Expression by H2S -- Regulation of iNOS Expression by H2S -- Regulation of nNOS Expression by H2S -- Regulation of CBS, CSE, or 3-MST by NO -- Support of the NO/cGMP/PKG Signaling Axis by H2S -- H2S, a Redox Reactivator of Soluble ­Guanylate Cyclase.H2S, an "Endogenous Viagra": Inhibition of PDE Activity by H2S -- Direct Reaction of H2S With cGMP: Formation of 8-SH-cGMP -- Oxidative Activation of Protein Kinase G by Sulfide-Derived Polysulfides -- Support of NO Signaling Through H2S/ROS Interactions -- Implications -- Implications of the NO/H2S Cooperative Interactions for the Regulation of Vascular Tone, Vascular Growth, and Remodeling -- Potential Cooperative Actions of NO and H2S in the Central and Peripheral Nervous System -- Potential Cooperative Actions of NO and H2S in Cancer -- On the Interdependence of NO and H2S Signaling and Cytoprotection -- Outlook: Future Therapeutic Directions -- References -- Chapter 6 - Heme Protein Metabolism of NO and Nitrite -- Introduction -- NO Inactivation by Reaction With Heme Proteins -- NO Reactions With Ferrous Hemoglobins to Form Iron-Nitrosyl Complexes [Fe(II)-NO] -- Effects of Red Blood Cell Compartmentalization of Hemoglobin on NO Reaction Rates -- NO Generation by Reaction of Nitrite With Deoxygenated Heme Proteins -- Conclusions -- Acknowledgments -- References -- Chapter 7 - Cross-Regulation Between iNOS/NO and Wnt/β-Catenin Signaling Pathways -- List of Abbreviations -- Introduction -- NO-Induced Posttranslational Modification of Wnt/β-Catenin Signaling Proteins -- iNOS-Derived NO Promotes β-Catenin ­Phosphorylation -- iNOS-Derived NO Induces Nitration and S-Nitrosation of Proteins Related to Wnt/β-Catenin Signaling Pathway -- iNOS/NO Induces Genetic Changes of Wnt/β-Catenin Pathway-Related Components -- Mutation of β-Catenin -- Loss of APC Heterozygosity -- iNOS/NO Regulates Wnt/β-Catenin Signaling -- iNOS/NO Targets Wnt/β-Catenin Signaling -- iNOS/NO Inversed DKK1 Expression ­Upregulated Wnt/β-Catenin Pathway -- iNOS/NO Regulates Both β-Catenin/TCF and NF-kB Transcriptional Functions -- iNOS Physically Interacts With β-Catenin.Wnt/β-Catenin Signaling Regulates iNOS/NO Pathway -- iNOS is a Targeted Gene of Wnt/β-Catenin Pathway -- Wnt/β-Catenin Regulated NF-kB Depending on the Induction of iNOS -- Conclusions -- References -- Chapter 8 - Regulation and Physiological Functions of NO-Sensitive Guanylyl Cyclase -- Introduction -- Isoforms and Molecular Properties of NO-Sensitive GC -- Activation of NO-GC by NO -- Novel Activators of NO-GC -- NO-GC Sensitizers and Heme-Mimetics in Clinical Testing -- NO-GC Inhibitors -- The NO/cGMP Signaling Cascade -- NO/cGMP-Induced Physiological Functions as Deduced From Genetic Deletion -- Blood Pressure Control -- Significance of NO-GC in Platelets -- Modulation of Synaptic Transmission -- LTP Is Lost in Both NO-GC KOs -- NO/cGMP in Glutamatergic Neurons -- NO/cGMP in GABAergic Neurons -- References -- Chapter 9 - Uncoupling of eNOS in Cardiovascular Disease -- Synthesis and Function of Endothelial NO -- The Phenomenon of eNOS Uncoupling -- Molecular Mechanisms of eNOS Uncoupling -- Uncoupling of eNOS in Cardiovascular Disease -- Hypertension -- Diabetes -- Atherosclerosis -- Pharmacological Prevention of eNOS Uncoupling -- Conclusions -- References -- Chapter 10 - Synthesis, Actions, and Perspectives of Nitric Oxide in Photosynthetic Organisms -- Nitric Oxide Synthesis in Photosynthetic Organisms -- Structure, Diversity, and Occurrence of Nitric Oxide Synthases (NOS) in Photosynthetic Organisms: Canonical NOS Is Absent i... -- Photosynthetic Organisms Do Not Synthetize the Biopterin Cofactor Required by NOS: The Role of Tetrahydrofolate -- Plants Possess Alternative Sources for NO Production -- Actions and Targets of NO in Photosynthetic Organisms -- NO as a Bioactive Signaling Molecule of Stress Responses in Land Plants -- Implications of NO in the Stress Responses of the Aquatic Photosynthetic Microorganisms.NO Is a Key Player in Auxin-Mediated Processes Leading to Root Growth and Development -- Targets and Molecular Mechanisms Underpinning NO Actions in Photosynthetic Organisms -- The Potential of NOS to Improve the Fitness of Crop Plants -- Concluding Remarks and Perspectives -- References -- Chapter 11 - Mitochondria and Nitric Oxide -- Introduction -- Sources of NO of Relevance to Mitochondria -- NO Inhibition of Cytochrome c Oxidase -- S-Nitrosation of Respiratory Complex i and Other Mitochondrial Proteins -- Mitochondrial Generation and Effects of Nitrated Fatty Acids -- Mitochondrial Generation and Effects of Peroxynitrite -- Cellular NO Signaling Regulation of Mitochondrial Dynamics and Number -- Summary and Integration of Concepts -- Acknowledgments -- References -- Chapter 12 - Nitric Oxide Formation From Inorganic Nitrate -- Introduction -- Sources of Nitrate and Nitrite -- The Enterosalivary Circulation of Nitrate -- Dietary Nitrate and Gastric Cancer -- Intragastric Generation of Nitric Oxide -- Interactions Between Nitrite and Other Dietary Compounds -- Systemic NO Generation From Nitrite -- Nitrite as a Vasodilator -- Mechanisms of Nitrite Reduction -- Dietary Nitrate and Cardiovascular Function -- Blood Pressure -- Pulmonary Hypertension -- Leukocyte and Platelet Activation -- Diabetes and Metabolic Syndrome -- How Is Inorganic Nitrate Bioactivated? -- Ergogenic Effects of Dietary Nitrate -- Nutritional Aspects -- References -- Chapter 13 - Biochemistry of Molybdopterin Nitrate/Nitrite Reductases -- Introduction -- Microbial Nitrate Reductases -- Eukaryotic Nitrate and Nitrite Reductases -- Xanthine Oxidoreductase -- Nitrate/Nitrite and Reducing Substrates -- Microenvironmental pH -- O2 Concentration -- Immobilization of XO on the Endothelial Glycocalyx -- Isoform of XOR -- Aldehyde Oxidase -- Sulfite Oxidase.Mitochondrial Amidoxime Reducing Component.Nitric oxidePhysiological effectNitric oxidePathophysiologyNitric oxidePhysiological effect.Nitric oxidePathophysiology.572/.53572.53Ignarro Louis J1739122Freeman Bruce1739123MiAaPQMiAaPQMiAaPQBOOK9910583324303321Nitric Oxide4163019UNINA05205nam 22007215 450 991030013360332120250609111806.03-319-92001-410.1007/978-3-319-92001-6(CKB)4100000005323083(DE-He213)978-3-319-92001-6(MiAaPQ)EBC5479049(PPN)229502830(MiAaPQ)EBC6237349(EXLCZ)99410000000532308320180728d2018 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierAdvanced Boundary Element Methods Treatment of Boundary Value, Transmission and Contact Problems /by Joachim Gwinner, Ernst Peter Stephan1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (XVIII, 652 p. 69 illus., 18 illus. in color.)Springer Series in Computational Mathematics,0179-3632 ;523-319-92000-6 1 Introduction -- 2 Some Elements of Potential Theory -- 3 A Fourier Series Approach -- 4 Mixed BVPs, Transmission Problems and Pseudodifferential Operators -- 5 The Signorini Problem and More Nonsmooth BVPs and Their Boundary Integral Formulation -- 6 A Primer to Boundary Element Methods -- 7 Advanced BEM for BVPs in Polygonal/Polyhedral Domains: h- and p-Versions -- 8 Exponential Convergence of hp-BEM -- 9 Mapping Properties of Integral Operators on Polygons -- 10 A-BEM -- 11 BEM for Contact Problems -- 12 FEM-BEM Coupling -- 13 Time-Domain BEM -- A Linear Operator Theory -- B Pseudodifferential Operators -- C Convex and Nonsmooth Analysis, Variational Inequalities -- D Some Implementation for BEM -- References -- Index.This book is devoted to the mathematical analysis of the numerical solution of boundary integral equations treating boundary value, transmission and contact problems arising in elasticity, acoustic and electromagnetic scattering. It serves as the mathematical foundation of the boundary element methods (BEM) both for static and dynamic problems. The book presents a systematic approach to the variational methods for boundary integral equations including the treatment with variational inequalities for contact problems. It also features adaptive BEM, hp-version BEM, coupling of finite and boundary element methods – efficient computational tools that have become extremely popular in applications. Familiarizing readers with tools like Mellin transformation and pseudodifferential operators as well as convex and nonsmooth analysis for variational inequalities, it concisely presents efficient, state-of-the-art boundary element approximations and points to up-to-date research. The authors are well known for their fundamental work on boundary elements and related topics, and this book is a major contribution to the modern theory of the BEM (especially for error controlled adaptive methods and for unilateral contact and dynamic problems) and is a valuable resource for applied mathematicians, engineers, scientists and graduate students.Springer Series in Computational Mathematics,0179-3632 ;52Integral equationsNumerical analysisDifferential equations, PartialCalculus of variationsApplied mathematicsEngineering mathematicsMathematical physicsIntegral Equationshttps://scigraph.springernature.com/ontologies/product-market-codes/M12090Numerical Analysishttps://scigraph.springernature.com/ontologies/product-market-codes/M14050Partial Differential Equationshttps://scigraph.springernature.com/ontologies/product-market-codes/M12155Calculus of Variations and Optimal Control; Optimizationhttps://scigraph.springernature.com/ontologies/product-market-codes/M26016Mathematical and Computational Engineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/T11006Theoretical, Mathematical and Computational Physicshttps://scigraph.springernature.com/ontologies/product-market-codes/P19005Integral equations.Numerical analysis.Differential equations, Partial.Calculus of variations.Applied mathematics.Engineering mathematics.Mathematical physics.Integral Equations.Numerical Analysis.Partial Differential Equations.Calculus of Variations and Optimal Control; Optimization.Mathematical and Computational Engineering.Theoretical, Mathematical and Computational Physics.515.45Gwinner Joachimauthttp://id.loc.gov/vocabulary/relators/aut767710Stephan Ernst Peterauthttp://id.loc.gov/vocabulary/relators/autBOOK9910300133603321Advanced Boundary Element Methods2235887UNINA