02023nam 2200361 450 991058303500332120230120002806.00-12-813039-3(CKB)4100000006670312(MiAaPQ)EBC5511118(EXLCZ)99410000000667031220180927d2019 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierLate-stage fluorination of bioactive molecules and biologically-relevant substrates /Al PostigoAmsterdam, Netherlands ;Oxford, England ;Cambridge, England :Elsevier,2019.1 online resource (498 pages) illustrations0-12-812958-1 Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work. Highlights the latest developments in the field in a concise volume. Provides details of key fluorinating reagents across diverse families of organic compounds. Explores the current applications and future potential of fluorine in drug development.FluorinationFluorination.547.2Postigo Al903317MiAaPQMiAaPQMiAaPQBOOK9910583035003321Late-stage fluorination of bioactive molecules and biologically-relevant substrates2019435UNINA