03015nam 2200409 450 991058302630332120230120002756.00-12-804268-00-12-804227-3(CKB)4100000005956446(MiAaPQ)EBC5495625(EXLCZ)99410000000595644620180919d2019 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierRisk assessment for human metal exposures mode of action and kinetic approaches /Gunnar F. Nordberg, Bruce A. FowlerFirst edition.London, United Kingdom :Academic Press, an imprint of Elsevier,[2019]©20191 online resource (350 pages)Metal exposures and human health -- historical development, current importance, and toxicological concepts for prevention -- Exposure, internal dose, and toxicokinesis (TK) -- Biomonitoring, mode of action (MOA), target dose, and adverse outcome pathways (AOPs) -- Hazard identification and assessment -- Dose-effect and dose-response assessment -- Dose-response for essential metals and the evaluation of mixed exposures -- Applied risk assessment, hazard assessment, and risk management -- Examples of risk assessments of human metal exposures and the need for mode of action (MOA), toxicokinetic-toxicodynamic (TKTD) modeling, and adverse outcome pathways (AOPs).Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA -TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication-the classic risk assessment paradigm-with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment.--Source other than the Library of Congress.MetalsToxicologyMetalsToxicology.615.9253Nordberg Gunnar16460Fowler Bruce A.MiAaPQMiAaPQMiAaPQBOOK9910583026303321Risk assessment for human metal exposures1933233UNINA