04510nam 2201009z- 450 991058021390332120231214133523.0(CKB)5690000000011949(oapen)https://directory.doabooks.org/handle/20.500.12854/87533(EXLCZ)99569000000001194920202207d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNeurotransmitter-Related Molecular Modeling StudiesBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (188 p.)3-0365-4277-9 3-0365-4278-7 This book focuses of the neurotransmission phenomenon. By definition, neurotransmitters are chemicals that enable communication, i.e., the flow of nerve impulses between nerve cells or between nerve cells and muscles and glands. Recently, one can distinguish excitatory and inhibitory mediators, both of which are endo–exogenous compounds that control the function of the whole organism. From a chemical point of view, neurotransmitters belong to many different structural groups, such as amino acids (such as glycine), peptides (such as substance P, somatostatin), monoamines (such as noradrenaline or dopamine), purine derivatives (such as adenosine), gases (such as nitrogen, NO, carbon monoxide CO), and acetylcholine. From a medical point of view, disturbances in the concentration of neurotransmitters in the body result in the occurrence of mental disorders and diseases (such as depression, schizophrenia, Parkinson’s disease) and contribute to the occurrence of dementia (including Alzheimer’s disease), among other diseases. However, the problem is much wider. These disorders can lead to a number of cardiovascular diseases and can lead to the development of vascular diseases of the brain as well as in many other organs. Therefore, pharmacological intervention is a therapy that tries to interfere with regulatory processes year after year. Such treatments improve survival, reduce the frequency of readmission, and improve patients' quality of life.Research & information: generalbicsscChemistrybicsscwhite matter hyperintensitiesdysautonomiagenetic polymorphismsdementialevodoparenin-angiotensin systemorthostatic hypotensionreserpine-induced fibromyalgia modelvortioxetineropiniroleserotonin and dopamine in fibromyalgiamousedopamineacetylcholineglutamateBDNFserotoninneurotransmittersstatinsneurodegenerative diseasesstrokedepressionandrogenetic alopecia3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitorsmixed dyslipidemiarisk factorshalogenated pyrazolinesmonoamine oxidase inhibitorskineticsreversibilitymolecular dynamicsguanylate cyclase (GC)chronic heart failure (CHF)pulmonary arterial hypertension (PAH)tiagabinecardiac voltage-gated ion channelsmolecular modelingECG studySGLT2isodium-glucose cotransporter 2 inhibitorsneuroprotectionatheroprotectionmTORtype 2 diabetes mellituscognitive impairmentinflammationoxidative stressantibioticsneurotoxicityadverse drug reactionneurotransmission5-HT receptorsgastrointestinal tractResearch & information: generalChemistryNowaczyk Alicjaedt1332311Grześk GrzegorzedtNowaczyk AlicjaothGrześk GrzegorzothBOOK9910580213903321Neurotransmitter-Related Molecular Modeling Studies3040814UNINA