04589nam 2201261z- 450 991058021350332120220706(CKB)5690000000011953(oapen)https://directory.doabooks.org/handle/20.500.12854/87433(oapen)doab87433(EXLCZ)99569000000001195320202207d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMicroRNA and CancerBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (298 p.)3-0365-4416-X 3-0365-4415-1 MicroRNAs (miRs) are small noncoding RNAs that function as post-transcriptional regulators of gene expression and have important roles in almost all biological pathways. Deregulated miR expression has been detected in numerous cancers, where miRs act as both oncogene and tumor suppressors. Due to their important roles in tumorigenesis, miRs have been investigated as prognostic and diagnostic biomarkers and as useful targets for therapeutic intervention. From a therapeutic point of view, two modalities can serve to rectify gene networks in cancer cells. For oncomiRs, a rational means is downregulation through antagomirs. Moreover, observations of the pathological reductions in tumor-suppressive miRs have inspired the concept of "miR replacement therapy" to enhance the amount of these miRs, thereby restoring them to normal levels. However, the clinical applicability of miR-based therapies is severely limited by the lack of effective delivery systems. Therefore, to understand the role of this new class of regulators, we need to identify the mRNA targets regulated by individual miRs as well as to develop specific, efficient, and safe delivery systems for therapeutic miRs.Biology, life sciencesbicsscResearch & information: generalbicssc2'-O-methylationadipokinesB-CLLbioinformatics analysisbiomarkerblood biomarkerbrain tumourbreast cancerBreast cancercancer stem cellcancer stem cellsccRCCcirculating biomarkerscirculating microRNAcolon cancerCyclooxygenase-2 (COX-2)deformabilitydiagnosisendometrial cancerestrogensexosomehead and neck squamous cell carcinomahepatocellular carcinomahyperinsulinemiaHypoxia inducible factor 1-alpha (HIF-1α)immune checkpoint inhibitorsimmunotherapyinsulininsulin resistanceinsulin signalinginsulin-like growth factorsmalignant melanomamedulloblastomameta-analysismetastasismetastatic melanomamethylationmicroRNAMicroRNA (miRNA)microRNAsMigrationmiR-584-5pmiR526bmiR655miRNAmiRNA-transcription factor networkmiRNAsn/anon-small cell lung cancernormal B-cell developmentovarian cancerOxidative stressPARPPI3K/Aktplasmapredictionprognosisprognostic factorprogressionProstaglandin E2 receptor 4 (EP4)pseudouridylationRCCregulationrenal cancerreplication stressserum LDHsmokingsnoRNAstem cellsstemnesssubgroupssurvivaltargeted therapytherapyYKT6Biology, life sciencesResearch & information: generalTucci Paolaedt1304525Tucci PaolaothBOOK9910580213503321MicroRNA and Cancer3027525UNINA