04936nam 2201225z- 450 991058021270332120220706(CKB)5690000000011961(oapen)https://directory.doabooks.org/handle/20.500.12854/87484(oapen)doab87484(EXLCZ)99569000000001196120202207d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierHospital Acquired Infections, Multidrug Resistant (MDR) Bacteria, Alternative Approaches to Antibiotic TherapyBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (206 p.)3-0365-4418-6 3-0365-4417-8 Bacterial resistance to known and currently used antibiotics represents a growing issue worldwide. It poses a major problem in the treatment of infectious diseases in general and hospital-acquired infections in particular. This is in part due to the overuse and misuse of antibiotics in past decades, which led to the selection of highly resistant bacteria and even so-called superbugs - multidrug-resistant (MDR) bacteria. Nosocomial infections, particularly, are often caused by MDR bacterial pathogens and the treatment of such infections is very complicated and extensive, often leading to various side effects, including adverse effects on the natural human microbiome. At the same time, the development of novel antibiotics is lagging with very few new ones in the pipeline. Finding viable alternatives to treat such infections may help to overcome these therapeutic issues. This publication brings novel developments in the field of bacterial resistance, mainly in the hospital settings, adequate antibiotic therapy, and identification of compounds useful to battle this growing issue.Hospital Acquired Infections, Multidrug Resistant Epidemiology and Medical statisticsbicsscMedicine and Nursingbicssc23S rRNAAMRantibiotic resistanceantibiotic stewardshipantibiotic therapyantimicrobial resistanceantimicrobial stewardshipbacteriaC. difficilecancer patientscarbapenem-resistant Acinetobacter baumanniicarbapenem-resistant Klebsiella pneumoniaeclinical impactclonal analysisclonal spreadclonalitycluster analysiscolistinconsumption of antibioticscritically ill patientsduration of treatmenteconomic impactendogenous infectionenterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR)Enterococcus faecalisEnterococcus faeciumepidemiologyESBLESBL-producing Klebsiella pneumoniaeEscherichia coliEscherichia spp.GIThemato-oncological patientshopshospitalinfectioninfection prevention and controlKlebsiellaKlebsiella spp.linezolid resistancelong term care facilities (LTCF)MDRmethicillin-resistantmethicillin-resistant Staphylococcus aureus (MRSA)MLSTMRSAmultidrug resistance (MDR)multidrug-resistant Acinetobacter baumanniiN-acetylcysteinenewbornoptrAPCRporcine modelprimerprincipal component analysispropensity score analysispulsed-field gel electrophoresis (PFGE)rat modelresistanceSCCmec typingseptic shockspa typingStaphylococcus aureusurinary tract infectionurinary tract infectionsuropathogensUTIsventilator-associated pneumoniaVREEpidemiology and Medical statisticsMedicine and NursingBostik Paveledt1304524Kolar MilanedtBostik PavelothKolar MilanothBOOK9910580212703321Hospital Acquired Infections, Multidrug Resistant (MDR) Bacteria, Alternative Approaches to Antibiotic Therapy3027524UNINA