04858nam 2201369z- 450 991058021080332120231214133432.0(CKB)5690000000011980(oapen)https://directory.doabooks.org/handle/20.500.12854/87450(EXLCZ)99569000000001198020202207d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierSynthetic Peptides and Peptidomimetics: From Basic Science to Biomedical ApplicationsBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (274 p.)3-0365-4396-1 3-0365-4395-3 This Special Issue, entitled "Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications", has included both reviews and original research contributions focused on the chemical design and biomedical applications of structurally modified bioactive peptides. The papers collected show how successful this class of molecules still is, both as model molecules for studying the structure of proteins and as potential therapeutics and diagnostics, and also as laboratory tools for advanced basic and applied studies. The large scientific community working in this field is in fact very active and productive, and is making the most of the potential and versatility of these molecules to generate increasingly interesting and innovative molecules of therapeutic interest and to understand the fundamental molecular mechanisms of life.Synthetic Peptides and PeptidomimeticsResearch & information: generalbicsscBiology, life sciencesbicsscpolymerspeptidomimeticsAFMtransfectionmolecular modellingpeptideα-helixhydrocarbon staplingring-closing metathesisi,i + 1 stapleX-ray structuredeferoxamineRGD peptidesintegrinsradiodiagnosticsPET imagingretro-inverso peptidesanticancer peptidesdrug deliverypeptide antigensAβIAPPantimicrobial peptidespeptidesdiagnosticELISAmicroarrayPETSPECTimaging diagnosticnon-imaging diagnosticamphiphilic peptidesnon-viral gene deliverynanocarrierpeptide self-assembliesstimuli responsiveSARS-CoV-2FRETmolecular dockingmolecular dynamicsMM-GBSAdrug repurposingantiviralcancercyclic peptideintegrinαvβ3ALOS4melanomafluorescent peptideenvironment-sensitive fluorophorepeptide labelingluciferinmembrane-binding peptideantimicrobial peptideantitumor peptideRGD peptideantiproliferative activitychiralityconformational analysisdensity functional theory (DFT)ferrocenehydrogen bondspeptidomimeticX-rayprotein–protein interactions (PPIs)voltage-gated Na+ (Nav) channelsfibroblast growth factor 14 (FGF14)medium spiny neurons (MSNs)nucleus accumbens (NAc)neurotherapeuticscyclophilin A (CypA)apoptosis-inducing factor (AIF)human neuroblastoma SH-SY5Y cellsstaurosporine-mediated cell deathAIF(370-394) peptidecaspase-3PARPantifungalantibacterialpeptide-based therapiessynthetic peptidesResearch & information: generalBiology, life sciencesDoti Nunziannaedt1332309Ruvo MenottiedtDoti NunziannaothRuvo MenottiothBOOK9910580210803321Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications3040812UNINA