05944nam 2201597z- 450 991058021010332120220706(CKB)5690000000011987(oapen)https://directory.doabooks.org/handle/20.500.12854/87449(oapen)doab87449(EXLCZ)99569000000001198720202207d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Origin and Early Evolution of LifePrebiotic Systems Chemistry PerspectiveBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (320 p.)3-0365-4470-4 3-0365-4469-0 What is life? How, where, and when did life arise? These questions have remained most fascinating over the last hundred years. Systems chemistry is the way to go to better understand this problem and to try and answer the unsolved question regarding the origin of Life. Self-organization, thanks to the role of lipid boundaries, made possible the rise of protocells. The role of these boundaries is to separate and co-locate micro-environments, and make them spatially distinct; to protect and keep them at defined concentrations; and to enable a multitude of often competing and interfering biochemical reactions to occur simultaneously. The aim of this Special Issue is to summarize the latest discoveries in the field of the prebiotic chemistry of biomolecules, self-organization, protocells and the origin of life. In recent years, thousands of excellent reviews and articles have appeared in the literature and some breakthroughs have already been achieved. However, a great deal of work remains to be carried out. Beyond the borders of the traditional domains of scientific activity, the multidisciplinary character of the present Special Issue leaves space for anyone to creatively contribute to any aspect of these and related relevant topics. We hope that the presented works will be stimulating for a new generation of scientists that are taking their first steps in this fascinating field.Origin and Early Evolution of Life Biology, life sciencesbicsscResearch & information: generalbicsscacetyleneADE theoryaggregation processamino acidsaminoacyl-tRNA synthetase classesanalogue conditionsastrobiologyastrochemistryautocatalytic setbending modulusbilayer structurebistable reaction systembuddingcell divisionchemical complexitychemical evolutionchirogenesisCHNOPScodon assignmentcognitioncometscompartmentcomplex organic moleculescyclic nucleotidesdimerizationdivisiondynamic kinetic stabilityearly Earthearly metabolismemergence of biological systemsevolutionexoplanetsFenton chemistryFRET analysisGC×GC-TOFMSglucose oxidaseglycocodon theoryhot springshydrothermal conditionsinterstellar mediumlipidlipid membraneMarsmetabolismmetal ionsmineralsmolecular dynamicsmolecular icesN-acyl amino acidn/anetwork expansion simulationolivineorigin of genetic codeorigin of lifeorigin-of-lifeorigins of lifeosmotic pressurepeptidyl-transferase centerpolymerizationprebiotic chemical evolutionprebiotic chemistryprebiotic membranesprimordial replicatorsprotein-monosaccharide interactionsprotein-monosaccharide recognitionproto-metabolismproto-ribosomeprotoamphiphilesprotocellprotoplanetary diskspseudo-symmetrypyrophosphatequartzradiation damagereduced phosphorusribozymesribozyvirusesRNA ligationsample returnschreibersiteselectionserpentinitesolid interfacesolid statestandard genetic codesstar forming regionsSymRsystems chemistrytemperaturetemplate-directed RNA synthesisthermodynamicsthiophenetime order of canonical amino acidstransition elementstransition metal sulfidestRNAulexiteurea-urease enzymatic reactionvesiclesviroidsBiology, life sciencesResearch & information: generalFiore Micheleedt1312140Altamura EmilianoedtFiore MicheleothAltamura EmilianoothBOOK9910580210103321The Origin and Early Evolution of Life3038915UNINA