04854nam 2201345z- 450 991058020540332120231214133149.0(CKB)5690000000012034(oapen)https://directory.doabooks.org/handle/20.500.12854/87472(EXLCZ)99569000000001203420202207d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierImmunotherapy, Tumor Microenvironment and Survival SignalingBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (376 p.)3-0365-4419-4 3-0365-4420-8 The book is based on the Cancers journal Special Issue entitled “Immunotherapy, Tumor Microenvironment and Survival Signaling", and focuses on important problems concerning tumors and tumor microenvironment interactions, as well as novel immunotherapies such as CAR-T cell therapy. Immunotherapies have recently shown remarkable results in the treatment of cancer patients. However, there are still many questions that remain to be solved in regards to more effective therapies, such as the tumor heterogeneous profile, tumor microenvironment, and tumor survival epigenetic and genetic pathways, all of which make patients resistant to the presently available treatments for cancer. This book demonstrates different approaches to overcome the challenges faced by immunotherapies due to suppressive tumor microenvironments. This book includes 18 papers that can be divided into three chapters: 1. novel immunotherapies; 2. targeting tumor microenvironment and novel approaches; 3. targeting tumors and tumor microenvironment in different types of cancer.MedicinebicsscClinical & internal medicinebicsscAutophagycolorectal cancerimmunotherapytumor stromatumor microenvironmentimmune checkpoint inhibitorschemotherapytyrosine kinase inhibitorsangiogenesischeck point inhibitorsprogrammed cell death protein 1programmed cell death 1 ligand 1cardiotoxicitylung metastasisCAR-ThypoxiatumormicroenvironmentCD19BCMAcancermelanomaimmune escapeantigen losschimeric antigen receptorelectroporationlentiviruslentiviral transductionmacrophagesleukemia cellslytic peptidestargeted therapydendritic cellspathogenesisrisk factorsbreast cancerresistancecheckpointtargeted treatmentpersonalized medicinepediatric solid tumorschimeric antigen receptorscancer vaccinesoncolytic viral therapyimmunomodulationDCLK1tumor stem cellsclonogenicitymitochondriamitochondrial transfertunneling nanotubestriple-negative breast cancerimmune checkpoint inhibitorcombination therapycancer nanomedicinetumor antigenscancer metabolismcancer immunotherapynanoparticlesimmunotherapeutic agentimmunomodulatorstuft cellscancer stem cellsimmunotherapiesmyeloid-derived suppressor cellsregulatory T cellscrosstalktumor immune evasioncell-cell contactβ2 integrinsCD18CD11CAR-T cellsCD37cell therapytumor antigenlymphomaCAR macrophageCAR T cellsolid tumorsimmunometabolismmiRNAimmunogenic cell deathMedicineClinical & internal medicineGolubovskaya Vitaedt1304516Golubovskaya VitaothBOOK9910580205403321Immunotherapy, Tumor Microenvironment and Survival Signaling3027516UNINA