04917nam 2201369z- 450 991058020540332120220706(CKB)5690000000012034(oapen)https://directory.doabooks.org/handle/20.500.12854/87472(oapen)doab87472(EXLCZ)99569000000001203420202207d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierImmunotherapy, Tumor Microenvironment and Survival SignalingBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (376 p.)3-0365-4419-4 3-0365-4420-8 The book is based on the Cancers journal Special Issue entitled "Immunotherapy, Tumor Microenvironment and Survival Signaling", and focuses on important problems concerning tumors and tumor microenvironment interactions, as well as novel immunotherapies such as CAR-T cell therapy. Immunotherapies have recently shown remarkable results in the treatment of cancer patients. However, there are still many questions that remain to be solved in regards to more effective therapies, such as the tumor heterogeneous profile, tumor microenvironment, and tumor survival epigenetic and genetic pathways, all of which make patients resistant to the presently available treatments for cancer. This book demonstrates different approaches to overcome the challenges faced by immunotherapies due to suppressive tumor microenvironments. This book includes 18 papers that can be divided into three chapters: 1. novel immunotherapies; 2. targeting tumor microenvironment and novel approaches; 3. targeting tumors and tumor microenvironment in different types of cancer.Clinical and internal medicinebicsscMedicine and Nursingbicsscangiogenesisantigen lossAutophagyBCMAbreast cancercancercancer immunotherapycancer metabolismcancer nanomedicinecancer stem cellscancer vaccinesCAR macrophageCAR T cellCAR-TCAR-T cellscardiotoxicityCD11CD18CD19CD37cell therapycell-cell contactcheck point inhibitorscheckpointchemotherapychimeric antigen receptorchimeric antigen receptorsclonogenicitycolorectal cancercombination therapycrosstalkDCLK1dendritic cellselectroporationhypoxiaimmune checkpoint inhibitorimmune checkpoint inhibitorsimmune escapeimmunogenic cell deathimmunometabolismimmunomodulationimmunomodulatorsimmunotherapeutic agentimmunotherapiesimmunotherapylentiviral transductionlentivirusleukemia cellslung metastasislymphomalytic peptidesmacrophagesmelanomamicroenvironmentmiRNAmitochondriamitochondrial transfermyeloid-derived suppressor cellsn/ananoparticlesoncolytic viral therapypathogenesispediatric solid tumorspersonalized medicineprogrammed cell death 1 ligand 1programmed cell death protein 1regulatory T cellsresistancerisk factorssolid tumorstargeted therapytargeted treatmenttriple-negative breast cancertuft cellstumortumor antigentumor antigenstumor immune evasiontumor microenvironmenttumor stem cellstumor stromatunneling nanotubestyrosine kinase inhibitorsβ2 integrinsClinical and internal medicineMedicine and NursingGolubovskaya Vitaedt1304516Golubovskaya VitaothBOOK9910580205403321Immunotherapy, Tumor Microenvironment and Survival Signaling3027516UNINA