03815nam 2201093z- 450 991058020530332120220706(CKB)5690000000012035(oapen)https://directory.doabooks.org/handle/20.500.12854/87477(oapen)doab87477(EXLCZ)99569000000001203520202207d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierParadox Role of Oxidative Stress in CancerState of the ArtBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (214 p.)3-0365-4421-6 3-0365-4422-4 Reactive oxygen species (ROS) are produced by healthy cells and are maintained at physiological levels by antioxidant systems. However, when ROS increase in number, a condition of oxidative stress occurs, leading to many human diseases, including cancer. The relationship between oxidative stress and cancer is complex since ROS play a double-edged role in cancer development and under therapy response. This paradox represents a great challenge for researchers and needs to be investigated. The articles collected in this Special Issue can help to clarify the role of ROS modulation in cancer prevention and treatment, and to dissect the molecular mechanisms underlying its paradoxical role in order to counteract carcinogenesis or enhance sensitivity to anticancer therapy.Paradox Role of Oxidative Stress in Cancer Medicine and NursingbicsscOncologybicsscantitumor agentsapoptosisbioinorganic chemistrybiomarkerbreast cancer treatmentcancer progressioncancer stem cellscancer therapycancer treatmentcancerogenesiscarbon doped titanium dioxidechemoresistancecold atmospheric plasmacombined treatmentcoordination polymersDNA damageEprenetapoptErastinferroptosisglutathioneglutathione (GSH)GPX4hematological malignanciesHO-1hyperforinHypericum perforatumimmune systeminflammatory signalingironleukemialipid peroxidationlymphomamitochondriamultiple myeloman/anatural compoundsnitriteNrf2NRF2oral canceroxidative stresspancreatic cancerpatientspH regulationprognosisradiotherapyreactive oxygen and nitrogen speciesreactive oxygen speciesSLC7A11sonodynamic therapysonosensitizerstherapytumor preventiontumor therapyultrasoundultraviolet-C (UVC)withanolideZEB-1Medicine and NursingOncologyDomenicotti Cinziaedt1329334Marengo BarbaraedtDomenicotti CinziaothMarengo BarbaraothBOOK9910580205303321Paradox Role of Oxidative Stress in Cancer3039443UNINA