03754nam 2201069z- 450 991058020530332120231214133158.0(CKB)5690000000012035(oapen)https://directory.doabooks.org/handle/20.500.12854/87477(EXLCZ)99569000000001203520202207d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierParadox Role of Oxidative Stress in CancerState of the ArtBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (214 p.)3-0365-4421-6 3-0365-4422-4 Reactive oxygen species (ROS) are produced by healthy cells and are maintained at physiological levels by antioxidant systems. However, when ROS increase in number, a condition of oxidative stress occurs, leading to many human diseases, including cancer. The relationship between oxidative stress and cancer is complex since ROS play a double-edged role in cancer development and under therapy response. This paradox represents a great challenge for researchers and needs to be investigated. The articles collected in this Special Issue can help to clarify the role of ROS modulation in cancer prevention and treatment, and to dissect the molecular mechanisms underlying its paradoxical role in order to counteract carcinogenesis or enhance sensitivity to anticancer therapy.Paradox Role of Oxidative Stress in Cancer MedicinebicsscOncologybicsscsonodynamic therapycarbon doped titanium dioxidesonosensitizersultrasoundcancer treatmentbreast cancer treatmentradiotherapyhematological malignanciesoxidative stresslymphomaleukemiamultiple myelomaapoptosismitochondriaultraviolet-C (UVC)withanolidecombined treatmentoral cancerDNA damagecancer therapyimmune systemHypericum perforatumhyperforinreactive oxygen speciespH regulationtumor preventiontumor therapycancerogenesisinflammatory signalingnatural compoundspancreatic cancerantitumor agentscoordination polymersbioinorganic chemistrycold atmospheric plasmareactive oxygen and nitrogen speciesnitritecancer stem cellschemoresistanceglutathionelipid peroxidationZEB-1GPX4ferroptosisHO-1Nrf2cancer progressionpatientstherapyprognosisbiomarkerEprenetapoptErastinglutathione (GSH)SLC7A11ironNRF2MedicineOncologyDomenicotti Cinziaedt1329334Marengo BarbaraedtDomenicotti CinziaothMarengo BarbaraothBOOK9910580205303321Paradox Role of Oxidative Stress in Cancer3039443UNINA