04416nam 22008175 450 991058014670332120251113175059.03-031-06850-510.1007/978-3-031-06850-8(MiAaPQ)EBC7021893(Au-PeEL)EBL7021893(CKB)24056041100041EBL7021893(AU-PeEL)EBL7021893(PPN)270268464(OCoLC)1333445629(DE-He213)978-3-031-06850-8(EXLCZ)992405604110004120220624d2022 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierAntiprotozoal Drug Development and Delivery /edited by Alane Beatriz Vermelho, Claudiu T. Supuran1st ed. 2022.Cham :Springer International Publishing :Imprint: Springer,2022.1 online resource (333 pages)Topics in Medicinal Chemistry,1862-247X ;39Description based upon print version of record.Print version: Vermelho, Alane Beatriz Antiprotozoal Drug Development and Delivery Cham : Springer International Publishing AG,c2022 9783031068492 Classical and Modern Drug Treatments for Leishmaniasis -- Saponins as Potential Antiprotozoa Agents -- Chagas Disease: Drug Development and Parasite Target -- Targeting carbonic anhydrases from Leishmania spp. and Trypanosoma cruzi as a strategy to obtain new drugs -- New Compounds for the Management of Trypanosoma brucei Infection -- Polyamine and Trypanothione Pathways as Targets for Novel Antileishmanial Drugs -- Nano and Microstructured Delivery Systems for Current Antileishmanial Drugs -- Pharmacological Treatment of Malaria -- η-Class Carbonic Anhydrases as Antiplasmodial Drug Targets: Current State of the Art and Hurdles to Develop New Antimalarials -- Management of Entamoeba histolytica Infection: Treatment Strategies and Possible New Drug Targets -- Trichomonas vaginalis Pharmacological Treatment -- Beta-Carbonic Anhydrase from Trichomonas Vaginalis as New Antiprotozoan Drug Target -- Drugs for the treatment of toxoplasmosis -- Challenges and promises for obtaining new antiprotozoal drugs – what’s going wrong?This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates. The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.Topics in Medicinal Chemistry,1862-247X ;39Pharmaceutical chemistrySynthetic biologyMedical microbiologyParasitologyMedicine, PreventiveHealth promotionBioinformaticsMedicinal ChemistrySynthetic BiologyMedical MicrobiologyParasitologyHealth Promotion and Disease PreventionComputational and Systems BiologyPharmaceutical chemistry.Synthetic biology.Medical microbiology.Parasitology.Medicine, Preventive.Health promotion.Bioinformatics.Medicinal Chemistry.Synthetic Biology.Medical Microbiology.Parasitology.Health Promotion and Disease Prevention.Computational and Systems Biology.615.7616.9883Supuran Claudiu T.Vermelho Alane BeatrizMiAaPQMiAaPQMiAaPQBOOK9910580146703321Antiprotozoal drug development and delivery2997520UNINA