03889nam 2200853z- 450 991057688800332120231214133428.0(CKB)5720000000008294(oapen)https://directory.doabooks.org/handle/20.500.12854/84432(EXLCZ)99572000000000829420202206d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAlbumin-Based Drug Delivery SystemsBasel :MDPI - Multidisciplinary Digital Publishing Institute,2022.1 electronic resource (162 pages)3-0365-4108-X 3-0365-4107-1 Albumin is playing an increasing role as a versatile, biodegradable drug carrier in clinical theranostics. By applying different techniques, smart drug-delivery systems can be developed from albumin in order to improve drug delivery of different active pharmaceutical ingredients, even small-molecule drugs, peptides or enzymes. Principally, three drug delivery technologies can be distinguished for binding small-molecule or peptide drugs through the charged amino acids, carboxyl, and amino groups of albumin: physical or covalent binding of the drug to albumin through a ligand- or protein-binding group, the fusion of drug with albumin or the encapsulation of drugs into albumin nanoparticles. The accumulation of albumin in inflamed tissues and solid tumours forms the rationale for developing albumin-based drug delivery systems for targeted drug delivery. Besides tumour therapy, albumin-based drug delivery systems can be successfully applied as anti-inflammatory and anti-thrombotic coating for medical devices. The development and optimization of albumin nanoparticles may also be a rational and promising tool for conventional or alternative administration routes in order to improve therapy. This collection provides an overview of the significant scientific research works in this field, which may inspire researchers towards further development and utilization of these smart drug delivery systems.Medicineplasma half-life extensionalbumin conjugationin vivo glucose-lowering activityglucagon-like peptide-1quality by designrapid equilibrium dialysismuco-adhesionbrain PAMPARPMI 2650 nasal epithelial cellhuman serum albumindimerizationdoxorubicinenhanced permeability and retention effectantitumorArthrobacter globiformisgouthalf-life extensioninverse electron demand Diels-Alder reactionsite-specific albumin conjugationthermostabilityurate oxidasealbuminanti-thromboticCD39coating of medical devicesstent coatingtherapeutic fusion proteinconjugatesvanadiumcancerprodrughydrogelsEPR/ESR spectroscopyrelease behaviordisulfidegliomaconjugatealbumin binding moietiespeptidesEvans blue4-(p-iodophenyl)butyric acidintegrin αvβ6integrin αvβ6 binding peptideimproved pharmacokineticsPET imagingMedicine.Katona GáborBOOK9910576888003321Albumin-Based Drug Delivery Systems3040922UNINA