04108nam 2200901z- 450 991057688800332120220621(CKB)5720000000008294(oapen)https://directory.doabooks.org/handle/20.500.12854/84432(oapen)doab84432(EXLCZ)99572000000000829420202206d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAlbumin-Based Drug Delivery SystemsBaselMDPI - Multidisciplinary Digital Publishing Institute2022Basel :MDPI - Multidisciplinary Digital Publishing Institute,2022.1 online resource (162 p.)3-0365-4108-X 3-0365-4107-1 Albumin is playing an increasing role as a versatile, biodegradable drug carrier in clinical theranostics. By applying different techniques, smart drug-delivery systems can be developed from albumin in order to improve drug delivery of different active pharmaceutical ingredients, even small-molecule drugs, peptides or enzymes. Principally, three drug delivery technologies can be distinguished for binding small-molecule or peptide drugs through the charged amino acids, carboxyl, and amino groups of albumin: physical or covalent binding of the drug to albumin through a ligand- or protein-binding group, the fusion of drug with albumin or the encapsulation of drugs into albumin nanoparticles. The accumulation of albumin in inflamed tissues and solid tumours forms the rationale for developing albumin-based drug delivery systems for targeted drug delivery. Besides tumour therapy, albumin-based drug delivery systems can be successfully applied as anti-inflammatory and anti-thrombotic coating for medical devices. The development and optimization of albumin nanoparticles may also be a rational and promising tool for conventional or alternative administration routes in order to improve therapy. This collection provides an overview of the significant scientific research works in this field, which may inspire researchers towards further development and utilization of these smart drug delivery systems.Manufacturing industriesbicsscMedicine and Nursingbicssc4-(p-iodophenyl)butyric acidalbuminalbumin binding moietiesalbumin conjugationanti-thromboticantitumorArthrobacter globiformisbrain PAMPAcancerCD39coating of medical devicesconjugateconjugatesdimerizationdisulfidedoxorubicinenhanced permeability and retention effectEPR/ESR spectroscopyEvans bluegliomaglucagon-like peptide-1gouthalf-life extensionhuman serum albuminhydrogelsimproved pharmacokineticsin vivo glucose-lowering activityintegrin αvβ6integrin αvβ6 binding peptideinverse electron demand Diels-Alder reactionmuco-adhesionpeptidesPET imagingplasma half-life extensionprodrugquality by designrapid equilibrium dialysisrelease behaviorRPMI 2650 nasal epithelial cellsite-specific albumin conjugationstent coatingtherapeutic fusion proteinthermostabilityurate oxidasevanadiumManufacturing industriesMedicine and NursingKatona GáborBOOK9910576888003321Albumin-Based Drug Delivery Systems3040922UNINA