04584nam 2201249z- 450 991057688290332120220621(CKB)5720000000008346(oapen)https://directory.doabooks.org/handle/20.500.12854/84515(oapen)doab84515(EXLCZ)99572000000000834620202206d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierBiomimetic Radical Chemistry and Applications 2021BaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (244 p.)3-0365-4350-3 3-0365-4349-X The high importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted considerable interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment, suitably designed to be a similar as possible to cellular conditions. This Special Issue provides readers with a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to be used as traces for the discoveries of some relevant biological processes. Several subjects are presented, with five articles and five reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications and bioinspired synthesis, with "free radicals" as the common denominator.ChemistrybicsscInorganic chemistrybicsscResearch & information: generalbicssc[4Fe-4S] clusteraggregationantibioticsbiomimetic chemistrybioorganometallic intermediatecatalase mimicscharge transferchemical nucleaseschemiluminescencecollagencopper complexescrosslinkcysteinedi-tryptophandi-tyrosinediiron-peroxo complexesdimerizationdisulfidesDNADNA biosensorDNA hole transferDNA oxidationDNA-drug interactionelectron transferEPR spectroscopyfree radicalsG-quadruplexguanineguanine radical cationguanyl radicalhyaluronic acidhydroxyl radicalinhibitorsIspHkeratoconusketone reductionkinetic studieskineticslaser flash photolysislight emissionLytBmass spectrometryMEP pathwaymetallodrugsmethioninemolecular dynamicsn/aneighboring group effectoligonucleotidesone-electron oxidantsoxidationpeptidesperoxideprotein oxidationproteinsproteomicspulse radiolysisquantum coherencequantum dynamicsradicalsreaction mechanismsreactive oxygen speciesreactive oxygen species (ROS)reductive dehydroxylationriboflavinsinglet oxygenSTEMstructure/activitytautomerismthiolstime-resolved spectroscopiestriplet state of carboxybenzophenoneChemistryInorganic chemistryResearch & information: generalChatgilialoglu Chryssostomosedt1311974Chatgilialoglu ChryssostomosothBOOK9910576882903321Biomimetic Radical Chemistry and Applications 20213030641UNINA