04148nam 2201033z- 450 991057688150332120231214133145.0(CKB)5720000000008360(oapen)https://directory.doabooks.org/handle/20.500.12854/84478(EXLCZ)99572000000000836020202206d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMitochondria-targeted drug deliveryBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (290 p.)3-0365-4039-3 3-0365-4040-7 Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells’ energy centers. Besides the production of ATP through cellular respiration, mitochondria play a pivotal role in other aspects of the life and death of a cell: heat production, programmed cell death, the regulation of metabolic activity, immunity, and calcium homeostasis. A number of diseases are associated with mitochondrial dysfunction, including cardiovascular, neurological, inflammatory, and metabolic disorders as well as cancer. Mitochondria therefore represent an important therapy target, and it is not surprising that a number of different treatment strategies have emerged. Approaches targeting mitochondria can be split into two opposite categories: drugs that restore mitochondrial function and drugs that trigger mitochondria-mediated cell death. Targeted drug delivery to achieve the selective accumulation of drug molecules in mitochondria is complex and involves methods such as direct drug modification or encapsulation into nanocarriers.Research & information: generalbicsscBiology, life sciencesbicsscretinal ischemiablood-brain barrierendothelialreactive oxygen speciesoxidative stresstunneling nanotubulesneuroncentral nervous systeminflammationhypoxiaanticancer peptide (ACP)antimicrobial peptide (AMP)anticancer peptidesantimicrobial peptideshost defense peptidespredictionrandom forestmitochondriamitochondrial DNAmitochondrial disorderspharmacological therapygene therapyprecision medicinecardiovascular diseasedrug deliverymitochondria dysfunctionsnanocarriersoxoglutarate carriermalate-aspartate shuttlecancer metabolismATP productiondiphenyleneiodoniumNADPH-oxidasedifferentiationproliferationmitochondria-targeted antioxidantsLPSmitochondrial ROSantitumor agentsfluorescence lifetime imagingmedicinal chemistrymetabolic drugmitochondrial carriermelanomaplumbagincytotoxic effectmetabolismcholesterollipid raftmitochondrial permeability transition porealkylphospholipid analogedelfosinemitochondrial oncometabolitescancer drug resistancemitochondrial diseaseheteroplasmymitochondrial gene deliveryResearch & information: generalBiology, life sciencesKopecka Joannaedt1326492Kopecka JoannaothBOOK9910576881503321Mitochondria-targeted drug delivery3037563UNINA