04243nam 2201033z- 450 991057687860332120231214133250.0(CKB)5720000000008389(oapen)https://directory.doabooks.org/handle/20.500.12854/84450(EXLCZ)99572000000000838920202206d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRole of MicroRNA in Cancer Development and TreatmentBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (280 p.)3-0365-3806-2 3-0365-3805-4 Many researchers around the world have demonstrated that the expression of miRNAs is dysregulated in different tumors. Such dysregulation is caused by multiple mechanisms, and exposure to different carcinogens causes dysregulated epigenetic changes and defects in the miRNA biogenesis machinery. Cancer cells with abnormal miRNA expression evolve the capability to sustain proliferative signaling, evade growth suppressors, resist cell death, activate invasion and metastasis, and induce angiogenesis. Genome-wide profiling demonstrates that miRNA expression signatures are associated with tumor type, tumor grade and clinical outcomes, so miRNAs could be potential candidates for diagnostic biomarkers, prognostic biomarkers, therapeutic targets and preventive screening programs. Although miRNAs have multiple targets, their function in tumorigenesis is due to their regulation of a few specific targets. After the first detection of altered miRNA in leukemia, microRNAs have been demonstrated to be constantly altered in all cancer. More recently, microRNA has been shown to be altered by exposure to environmental carcinogens, thus driving the whole process of carcinogenesis. Our aim is to provide a rigorous peer review and publish cutting-edge research on the role of microRNA in cancer prevention therapy to educate and inspire the scientific community worldwide.MedicinebicsscPharmacologybicsscbreast cancermiRNAsliquid biopsyangiogenesisbiomarkersearly diagnosisair pollutionbiomarkerexposurehumanlung cancermiRNAcarcinogenesismicroRNAasbestos exposureoral squamous cell carcinomadiagnosisprognosissalivaneuroblastomaMYCN amplificationmetastaseschemoresistancepublic health genomicsgenetic polymorphismsepigenetic modulationsgenetic and microbiome markershealth technology assessmentearly disease preventionnonsmokers lung cancerenvironmental risk factorsoncogenesmutationsglioblastomamicroRNAscancerqPCRcancer stem cellsplasticizersin vitro studyPRISMAno-smokers lung cancerDNA adductsmesotheliomaextracellular vesiclesmiR-625fluoro-edeniteasbestosmalignant mesotheliomacancer preventionmicrobiotaepigeneticsenvironmental pollutantscutaneous tissuesozone exposureMedicinePharmacologyPulliero Alessandraedt1326267Izzotti AlbertoedtPulliero AlessandraothIzzotti AlbertoothBOOK9910576878603321Role of MicroRNA in Cancer Development and Treatment3037235UNINA