04831nam 2201237z- 450 991057687520332120231214132825.0(CKB)5720000000008423(oapen)https://directory.doabooks.org/handle/20.500.12854/84526(EXLCZ)99572000000000842320202206d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierOpioids and Their ReceptorsPresent and Emerging Concepts in Opioid Drug Discovery IIBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (260 p.)3-0365-4352-X 3-0365-4351-1 Few neurotransmitter systems have fascinated as much as the opioid system (i.e., opioid ligands and their receptors). Over the years, scientific studies of the endogenous opioid system have uncovered a complex and subtle system that exhibits impressive diversity, based on its critical role in modulating a large number of sensory, motivational, emotional and cognitive functions. Additionally, its important therapeutic value for the treatment of many human disorders, including pain, affective and addictive disorders, and gastrointestinal motility disorders, has been of persistent interest. This book specifically covers a broad area of the opioid research, offering up-to-date and new perspectives about opioid drug discovery. The diversity among the discussed topics ranging from medicinal chemistry to opioid pharmacology, from basic science to translational research, is a testimony to the complexity of the opioid system that results from the expression, regulation and functional role of opioid ligands and their receptors. This book will serve as a useful reference to scientists while also stimulating continuous research in the chemistry and pharmacology of the opioid system, with the prospective for finding improved therapies of human diseases where the opioid system plays a central role.Opioids and Their Receptors Research & information: generalbicsscChemistrybicsscthiazolepiperazinetail-cliphot-plateacetic acid-induced writhing testopioidprodynorphinepigeneticstranscriptionhuman brainmorphine dosingbehaviorlocomotor activitytoleranceµ-opioid receptorDAMGOSR-17018buprenorphinenalbuphinekappa opioid receptor agonistpruritisscratchingmiceTAT-HIVcholestasischloroquinedeoxycholic acidanalgesicδ opioid receptorG-protein-biased agonistopioid peptiderubiscolinsµ-opioid analgesicsangiotensin receptorschronic painneuropathic paindelta opioid receptorinverse agonistirreversible antagonistnon-competitive antagonistmolecular pharmacologyfree fatty acid receptorslipidsopioid receptorcolitischemotypehigh-throughput screenallosteric modulationbeta-arrestinmolecular dynamicsopioid receptorsβ-amino acidspeptide synthesisreceptor binding studiesfunctional assaynociceptin/orphanin FQ receptorNOP receptorligandsnociceptinN/OFQanalgesiaGPCRHS-731peripheral opioid agonistbindingselectivitymolecular dockingmolecular dynamics simulationsfluorescence cross-correlation spectroscopy (FCCS)G protein-coupled receptor (GPCR)serotoninResearch & information: generalChemistrySpetea Marianaedt1304705van Rijn Richard MedtSpetea Marianaothvan Rijn Richard MothBOOK9910576875203321Opioids and Their Receptors3027635UNINA