06469nam 2201873z- 450 991057687370332120231214132825.0(CKB)5720000000008438(oapen)https://directory.doabooks.org/handle/20.500.12854/84580(EXLCZ)99572000000000843820202206d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPPARs as Key Mediators of Metabolic and Inflammatory RegulationMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (456 p.)3-0365-4192-6 3-0365-4191-8 Mounting evidence suggests a bidirectional relationship between metabolism and inflammation. Molecular crosstalk between these processes occurs at different levels with the participation of nuclear receptors, including peroxisome proliferator-activated receptors (PPARs). There are three PPAR isotypes, α, β/δ, and γ, which modulate metabolic and inflammatory pathways, making them key for the control of cellular, organ, and systemic processes. PPAR activity is governed by fatty acids and fatty acid derivatives, and by drugs used in clinics (glitazones and fibrates). The study of PPAR action, also modulated by post-translational modifications, has enabled extraordinary advances in the understanding of the multifaceted roles of these receptors in metabolism, energy homeostasis, and inflammation both in health and disease. This Special Issue of IJMS includes a broad range of basic and translational article, both original research and reviews, focused on the latest developments in the regulation of metabolic and/or inflammatory processes by PPARs in all organs and the microbiomes of different vertebrate species.Research & information: generalbicsscBiology, life sciencesbicsscBiochemistrybicsscnuclear receptorgene transcriptioninflammationmolecular dockingPPARβ/δlungpulmonary arteryGW0742GSK3787dockinglipopolysaccharide (LPS)PPARγ ligandcoumarinfluorescent ligandscreeningcrystal structurePPARatopic dermatitispsoriasismetabolic reprogramingglucosefatty acidsmycobacteriaM. tuberculosisM. lepraePPARslipid dropletsmetabolic alterationshepatic damagenuclear factorspharmacological targetsAMPKGDF15insulin resistancetype 2 diabetes mellitusperoxisome proliferator-activated receptor gamma (PPARγ)real-time PCRELISAimmunohistochemistrysignaling pathwayPPAR gammabrainneural stem cellsinfectionneuroinflammationHIVZikacytomegalovirusneurogenesismicroglialiver damagetoll-like receptor 4P2Y2 receptormetabolic syndromeresveratrolquercetinPPARαperoxisomeβ-oxidationPPREligandcoregulatormicronutrientsPPARα knockoutadipose tissuebrowninglipid metabolismdepressionPPARgneuropathologycorticotropin releasing hormonenorepinephrinesubgenual prefrontal cortexamygdalanucleus accumbenscommon carotid artery occlusionelectroretinographyfibroblast growth factor 21pemafibrateperoxisome proliferator-activated receptor alpharetinal ischemiaskeletal musclesubstrate metabolismnonalcoholic fatty liver disease (NAFLD)sex dimorphismlipidomicshepatic sex-biased gene expressionPPARγpulmonary arterial hypertensionTGFβvascular injuryproliferationkidney fibrosispattern-recognition receptorsphagocytosisnitric oxide synthasefenofibrateoleoylethanolamidepalmitoylethanolamidecancerimmunityobesitydiabetesmiRNADNA methylationhistone modificationperoxisome-proliferator-activated receptorfatty acid oxidationdoping controlregulatory T cellsexercisenuclear receptorsnutrigenomicsenergy homeostasisdairy animalsnon-alcoholic fatty liver disease (NAFLD)non-alcoholic steatohepatitis (NASH)peroxisome proliferator-activated receptors (PPAR)bezafibratefenofibric acidperoxisome proliferator-activated receptordual/pan agonistX-ray crystallographyResearch & information: generalBiology, life sciencesBiochemistryVázquez-Carrera Manueledt1311969Wahli WalteredtVázquez-Carrera ManuelothWahli WalterothBOOK9910576873703321PPARs as Key Mediators of Metabolic and Inflammatory Regulation3030636UNINA