04221nam 2200805 a 450 991078619520332120230803024808.00-8232-4543-80-8232-5077-60-8232-5031-810.1515/9780823245437(CKB)2670000000275486(EBL)3239774(SSID)ssj0000756877(PQKBManifestationID)11390541(PQKBTitleCode)TC0000756877(PQKBWorkID)10753576(PQKB)10481267(StDuBDS)EDZ0000155665(MiAaPQ)EBC3239774(OCoLC)822024944(MdBmJHUP)muse19479(DE-B1597)555130(DE-B1597)9780823245437(Au-PeEL)EBL3239774(CaPaEBR)ebr10611590(OCoLC)1178768982(MiAaPQ)EBC1132254(MiAaPQ)EBC4704535(Au-PeEL)EBL4704535(CaONFJC)MIL818119(EXLCZ)99267000000027548620120711d2013 uy 0engur|||||||nn|ntxtccrThe sense of semblance[electronic resource] philosophical analyses of Holocaust art /Henry W. Pickford1st ed.New York Fordham University Press20131 online resource (296 p.)Description based upon print version of record.0-8232-4540-3 Includes bibliographical references and index.Front matter --Contents --Illustrations --Acknowledgments --Introduction: The Judgment of Holocaust Art --2. Conflict and Commemoration --3. The Aesthetics of Historical Quotation --4. The Aesthetic-Historical Imaginary: --Conclusion: The Morality of Holocaust Art --Notes --Bibliography --Index"Holocaust artworks intuitively must fulfill at least two criteria: artistic (lest they be merely historical documents) and historical (lest they distort the Holocaust or become merely artworks). The Sense of Semblance locates this problematic within philosophical aesthetics, as a version of the conflict between aesthetic autonomy and heteronomy, and argues that Adorno's dialectic of aesthetic semblance describes the normative demand that artworks maintain a dynamic tension between the two. The Sense of Semblance aims to move beyond familiar debates surrounding postmodernism by demonstrating the usefulness of contemporary theories of meaning and understanding, including those from the analytic tradition. Pickford shows how the causal theory of names, the philosophy of tacit knowledge, the analytic philosophy of quotation, Sartre's theory of the imaginary, the epistemology of testimony, and Walter Benjamin's dialectical image can help explicate how individual artworks fulfill artistic and historical desiderata. In close readings of Celan's poetry, Holocaust memorials in Berlin, the quotational artist Heimrad Backer, Claude Lanzmann's film Shoah, and Art Spiegelman's graphic novel Maus, Pickford offers interpretations that, in their precision, specificity, and clarity, inaugurate a dialogue between contemporary analytic philosophy and contemporary art. The Sense of Semblance is the first book to incorporate contemporary analytic philosophy in interpretations of art and architecture, literature, and film about the Holocaust"--Provided by publisher.Holocaust, Jewish (1939-1945), and the artsAdorno.Bäcker.Celan.German/Austrian literature.Holocaust.Lanzmann.Spiegelman.aesthetics.film.graphic novel.memorials.Holocaust, Jewish (1939-1945), and the arts.700/.458405318LIT004210PHI001000HIS043000bisacshPickford Henry W1141462MiAaPQMiAaPQMiAaPQBOOK9910786195203321The sense of semblance3724554UNINA02855nam 2200637 450 991081264370332120210614063141.00-7391-8049-5(CKB)3710000000214120(EBL)1757682(OCoLC)886110372(SSID)ssj0001288878(PQKBManifestationID)11769957(PQKBTitleCode)TC0001288878(PQKBWorkID)11297108(PQKB)10889724(MiAaPQ)EBC1757682(Au-PeEL)EBL1757682(CaPaEBR)ebr10901680(CaONFJC)MIL633813(EXLCZ)99371000000021412020140814h20142014 uy 0engur|n|---|||||txtccrFrantz Fanon, my brother doctor, playwright, revolutionary /Joby Fanon ; translated by Daniel NetheryLanham, Maryland :Lexington Books,2014.©20141 online resource (156 p.)Critical Africana Studies : African, African American, and Caribbean Interdisciplinary and Intersectional StudiesDescription based upon print version of record.0-7391-8048-7 Includes bibliographical references and index.Frantz Fanon, My Brother; Contents; Foreword; 1. Preface; 2. Our Family; 3. Our Youth in Fort-de-France; 4. Our Schooling during the War; 5. Dissidence; 6. The Soldier; 7. Frantz and His Family; 8. Return to Martinique after the War; 9. Studies in France; 10. The Death of Our Father; 11. A Vacation in Nantua; 12. The Playwright; 13. Black Skin, White Masks; 14. The General Practitioner; 15. Blida; 16. Gabrielle; 17. The First Congress of Black Writers; 18. The Second Congress; 19. Tunis; 20. A Telegram; 21. Death and Burial; 22. Fanon and Martinique; 23. Fanon and Humanism; NotesBibliographyIndexFrantz Fanon stands as one of the most uncompromising critics of racism and colonialism. Translated into English by Daniel Nethery, this biography by Fanon''s brother, Joby, is an intimate, passionate, and very human account of one of the most influential thinkers of the twentieth century.Critical Africana studies.RevolutionariesAlgeriaBiographyIntellectualsAlgeriaBiographyPsychiatristsAlgeriaBiographyAlgeriaBiographyRevolutionariesIntellectualsPsychiatrists965/.046092Fanon Joby1923-1613247Nethery DanielMiAaPQMiAaPQMiAaPQBOOK9910812643703321Frantz Fanon, my brother3942438UNINA06634nam 22007695 450 991056826280332120260202154322.03-030-95334-310.1007/978-3-030-95334-8(MiAaPQ)EBC6963477(Au-PeEL)EBL6963477(CKB)21672596700041(PPN)262170140(OCoLC)1354205823(DE-He213)978-3-030-95334-8(EXLCZ)992167259670004120220426d2022 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierNovel Synthetic Drugs in Migraine /edited by Paolo Martelletti, Lars Edvinsson1st ed. 2022.Cham :Springer International Publishing :Imprint: Springer,2022.1 online resource (114 pages)Headache,2197-6538Print version: Martelletti, Paolo Novel Synthetic Drugs in Migraine Cham : Springer International Publishing AG,c2022 9783030953331 Includes bibliographical references.Intro -- Foreword -- Preface -- Contents -- Chapter 1: Novel Pharmacological Targets of Migraine: An Overview -- 1.1 Introduction -- 1.2 Novel Pharmacological Treatments for Migraine -- 1.3 Acute Treatment for Migraine Beyond Ergots and Triptans -- 1.3.1 5-HT1F Agonists: Ditans -- 1.3.2 CGRP Receptor Antagonists: Gepants -- 1.4 Gepants as Prophylactic Treatment for Migraine -- 1.5 Mechanisms of Action of Ditans and Gepants: Is It a Common Pathway? -- 1.6 Conclusion -- References -- Chapter 2: Molecular and Cellular Mechanisms of CGRP Antagonists -- 2.1 Introduction -- 2.1.1 Trigeminovascular System -- 2.2 Neuropeptide Signaling -- 2.2.1 CGRP -- 2.2.2 Amylin -- 2.2.3 Neuropeptide Receptors -- 2.2.4 Downstream Activation -- 2.3 The Blood-Brain Barrier -- 2.4 CGRP Antagonists -- 2.5 Molecular Targets -- 2.6 Cellular Targets -- 2.6.1 Vascular Targets -- 2.6.2 Trigeminal Targets -- 2.6.2.1 Satellite Glial Cells -- 2.6.2.2 Neuronal Targets -- 2.6.2.3 Potential Antagonistic Effect at the Nodes of Ranvier -- 2.7 Non-migraine Targets -- 2.8 Conclusion -- References -- Chapter 3: Atogepant -- 3.1 Introduction -- 3.2 Chemical Characteristics, Pharmacodynamics and Pharmacokinetics -- 3.3 Atogepant in Preclinical Studies -- 3.4 Efficacy of Atogepant in Phase II and Phase III Clinical Trials -- 3.5 Safety and Adverse Events -- 3.6 Future Developments -- 3.7 Conclusions -- References -- Chapter 4: Ubrogepant -- 4.1 Introduction -- 4.2 Pharmacology -- 4.2.1 Chemistry -- 4.2.2 Pharmacodynamics -- 4.2.3 Pharmacokinetics and Metabolism -- 4.3 Clinical Registered Trials -- 4.3.1 Phase I Trials -- 4.3.2 Phase II Trials -- 4.3.3 Phase III Trials: ACHIEVE I and II and Their Extension Study -- 4.3.4 Post-marketing Studies -- 4.4 Safety and Tolerability -- 4.5 Regulatory Affairs and Clinical Approval -- 4.6 Conclusions -- References -- Chapter 5: Rimegepant.5.1 Introduction -- 5.2 Introduction to the Compound -- 5.2.1 Chemistry -- 5.2.2 Pharmacodynamics -- 5.2.3 Pharmacokinetics and Metabolism -- 5.2.4 Metabolism -- 5.2.5 Drug Interactions -- 5.3 Clinical Efficacy -- 5.3.1 Phase II Studies -- 5.3.2 Phase III Studies -- 5.4 Safety and Tolerability -- 5.4.1 Phase I Studies -- 5.4.2 Phase II Studies -- 5.4.3 Phase III Studies -- 5.5 Exclusion Criteria -- 5.6 Conclusions -- References -- Chapter 6: Zavegepant -- 6.1 Introduction -- 6.2 Preclinical Pharmacology -- 6.3 Clinical Trials -- 6.3.1 Safety and Tolerability -- 6.3.2 Efficacy -- 6.4 Conclusion -- References -- Chapter 7: Molecular Mechanisms of 5-HT1F Receptor Agonists -- 7.1 Serotonin (5-HT) and 5-HT Receptors -- 7.2 5-HT1B/D and 5-HT1F Receptors and Migraine Treatment -- References -- Chapter 8: Lasmiditan -- 8.1 Introduction -- 8.2 Pharmacological Profile -- 8.3 Preclinical Studies -- 8.4 Clinical Studies -- 8.5 Safety -- 8.6 Drug Interactions -- 8.7 Conclusion -- References -- Chapter 9: Update on Old and Current Targets for Antimigraine Therapies -- 9.1 Introduction -- 9.2 Current Drugs for Acute Migraine -- 9.2.1 NSAIDs and Other Analgesics -- 9.2.2 5-Hydroxytryptamine Receptors in Migraine -- 9.2.3 Neurokinin Receptors and Blockers -- 9.2.4 Gepants -- 9.3 Targets for Prophylaxis of Migraine -- 9.3.1 Beta-Adrenoceptor Blockers -- 9.3.2 Angiotensin II AT1 Receptor Antagonists -- 9.3.3 Anticonvulsant Drugs -- 9.3.4 Tricyclic Antidepressant -- 9.3.5 Calcium Channel Antagonists -- 9.3.6 Onabotulinum Toxin A -- 9.4 Conclusion -- References.Published in the series Headache, endorsed by the European Headache Federation, this is the first book on the novel synthetic treatment of migraine with ditans (lasmiditan) and gepants (atogepant, ubrogepant, rimegepant, vazegepant). These drugs will provide additional options for people with migraine put at risk of side effects by other medications or with unsatisfactory response to previous drugs. There is now a sufficient amount of literature published to interest a wide multidisciplinary readership (general physicians, general neurologists, clinical psychologists, neurologists in training, and medical students) facing every day this burdensome disorder in their clinical practice. The book aims therefore at offering an overview of these new drugs for both acute and prophylactic treatments of migraine, covering studies on clinical evidence, tolerability, and the different stages of clinical development.Headache,2197-6538Internal medicineNeurologyEmergency medicinePain medicinePharmacologyInternal MedicineNeurologyEmergency MedicinePain MedicinePharmacologyMigranyathubLlibres electrònicsthubInternal medicine.Neurology.Emergency medicine.Pain medicine.Pharmacology.Internal Medicine.Neurology.Emergency Medicine.Pain Medicine.Pharmacology.Migranya615.1616.84912061Martelletti PaoloEdvinsson LarsMiAaPQMiAaPQMiAaPQBOOK9910568262803321Novel synthetic drugs in migraine2966507UNINA