03410nam 2200805z- 450 991056648550332120231214132950.0(CKB)5680000000037524(oapen)https://directory.doabooks.org/handle/20.500.12854/80968(EXLCZ)99568000000003752420202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierGastrointestinal Cancers and Personalized MedicineBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (136 p.)3-0365-3808-9 3-0365-3807-0 Gastrointestinal cancers, such as esophageal and gastric cancers, pancreatic cancers, hepatobiliary cancers, colorectal cancers and gastrointestinal stromal tumors, are frequently diagnosed at an advanced stage and have a dismal prognosis. Even in patients with potentially curative cancer, nearly 50\% will develop recurrent disease despite aggressive treatments. A number of biomarkers currently guide treatment decisions for patients with gastrointestinal neoplasms. Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, furthering oncology along the path to “personalized cancer medicine”. Future research efforts will focus on the identification of new biomarkers, moving existing biomarkers into earlier lines of therapy and evaluating new combinations of existing biomarkers and therapies.The aim of this Special Issue is to provide an overview of exciting new research in the area of gastrointestinal tumors that may establish innovative personalized management and precision medicine modalities for individualized care.MedicinebicsscPharmacologybicsscneutrophil-to-lymphocyte ratiolymphocyte-to-monocyte ratioprognosisrectal cancermesorectumsphincter preservingmolecular oncologyprecision medicinecolorectal cancertargeted therapymolecular profilingpancreatic cyststhermal liquid biopsydifferential scanning calorimetrydiagnosisgeneralized linear modelsgene signaturemRNA expressionVANGL1FFPEneurotoxicityoxaliplatinchemotherapy-induced peripheral neuropathybiomarkergenomicsneuropathyFOLFOXFOLFIRINOXXELOXgastrointestinal cancerLAG-3immune checkpointcolon cancersurvivalmicrosatellite instabilityimmunotherapyMedicinePharmacologyMini Enricoedt1314121Nobili StefaniaedtMini EnricoothNobili StefaniaothBOOK9910566485503321Gastrointestinal Cancers and Personalized Medicine3031732UNINA